Recurrence of tuberculosis among newly diagnosed sputum positive pulmonary tuberculosis patients treated under the Revised National Tuberculosis Control Programme, India: A multi-centric prospective study.
Recurrence of tuberculosis among newly diagnosed sputum positive pulmonary tuberculosis patients treated under the Revised National Tuberculosis Control Programme, India: A multi-centric prospective study.
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DOI：
10.1371/journal.pone.0200150
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发表时间：
2018
期刊：
影响因子：
3.7
通讯作者：
Natrajan M
中科院分区：
文献类型：
--
作者：
Velayutham B;Chadha VK;Singla N;Narang P;Gangadhar Rao V;Nair S;Ramalingam S;Narayanan Sivaramakrishnan G;Joseph B;Selvaraju S;Shanmugam S;Narang R;Pachikkaran P;Bhat J;Ponnuraja C;Bajaj Bhalla B;Shivashankara BA;Sebastian G;Yadav R;Kumar Sharma R;Sarin R;Myneedu VP;Singla R;Khayyam K;Mrithunjayan SK;Jayasankar SP;Sanker P;Viswanathan K;Viswambharan R;Mathuria K;Bhalla M;Singh N;Tumane KB;Dawale A;Tiwari CP;Bansod R;Jayabal L;Murali L;Khaparde SD;Rao R;Jawahar MS;Natrajan M
目前缺乏资料，说明根据《国家结核病控制规划修订本》接受6个月每周三次方案治疗的新的痰检阳性肺结核患者在治疗成功后复发结核病的比例。评估成功完成治疗的新诊断PTB患者的结核复发率，并记录内源性再激活或再感染。确定了治疗和结核病复发的不利结果的风险因素。从泰米尔纳德邦、卡纳塔克邦、德里、马哈拉施特拉邦、中央邦和喀拉拉邦的研究中心入组接受RNTCP治疗的成人（年龄≥ 18岁）新发涂阳PTB患者。在治疗结束时宣布“治疗成功”的患者在治疗完成后3、6和12个月各进行2次痰液检查。进行MIRU-VNTR基因分型以确定TB复发时的内源性再激活或外源性再感染。TB复发率表示为每100人-年的发生率（95%置信区间[95%CI]）。使用回归模型来确定对治疗的不利反应和结核病复发的风险因素。在1577例新登记的涂阳肺结核患者中，分析了1565例。总治愈率为77%（1207/1565），治疗成功率为77%（1210 /1565）。治愈率为65%~ 86%。1210例患者中有158例在治疗成功后复发。合并的TB复发估计值为10.9% [95%CI：0.2-21.6]，每100人年的TB复发率为12.7 [95%CI：0.4-25]。每100人-年的结核病复发率为5.4 - 30.5。在60例进行基因分型的患者中，有56例（93%）观察到内源性再激活。男性与结核病复发有关。在项目设置下，相当大比例的新涂阳PTB患者成功接受6个月每周三次方案治疗后出现结核复发。
There is lack of information on the proportion of new smear—positive pulmonary tuberculosis (PTB) patients treated with a 6-month thrice-weekly regimen under Revised National Tuberculosis Control Programme (RNTCP) who develop recurrent TB after successful treatment outcome. To estimate TB recurrence among newly diagnosed PTB patients who have successfully completed treatment and to document endogenous reactivation or re-infection. Risk factors for unfavourable outcomes to treatment and TB recurrence were determined. Adult (aged ≥ 18 yrs) new smear positive PTB patients initiated on treatment under RNTCP were enrolled from sites in Tamil Nadu, Karnataka, Delhi, Maharashtra, Madhya Pradesh and Kerala. Those declared “treatment success” at the end of treatment were followed up with 2 sputum examinations each at 3, 6 and 12 months after treatment completion. MIRU-VNTR genotyping was done to identify endogenous re-activation or exogenous re-infection at TB recurrence. TB recurrence was expressed as rate per 100 person-years (with 95% confidence interval [95%CI]). Regression models were used to identify the risk factors for unfavourable response to treatment and TB recurrence. Of the1577 new smear positive PTB patients enrolled, 1565 were analysed. The overall cure rate was 77% (1207/1565) and treatment success was 77% (1210 /1565). The cure rate varied from 65% to 86%. There were 158 of 1210 patients who had TB recurrence after treatment success. The pooled TB recurrence estimate was 10.9% [95%CI: 0.2–21.6] and TB recurrence rate per 100 person–years was 12.7 [95% CI: 0.4–25]. TB recurrence per 100 person–years varied from 5.4 to 30.5. Endogenous reactivation was observed in 56 (93%) of 60 patients for whom genotyping was done. Male gender was associated with TB recurrence. A substantial proportion of new smear positive PTB patients successfully treated with 6 –month thrice-weekly regimen have TB recurrence under program settings.
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DOI：
10.5588/ijtld.13.0585
发表时间：
2014-03
期刊：
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease
影响因子：
--
作者：
Sreeramareddy CT;Qin ZZ;Satyanarayana S;Subbaraman R;Pai M
通讯作者：
Pai M
DOI：
10.5455/ijmsph.2016.20062016529
发表时间：
2016-01-01
期刊：
International Journal of Medical Science and Public Health
影响因子：
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作者：
Vijayashree Yellappa, Vijayashree Yellappa;Vani Kandpal, Vani Kandpal;Tabassum, A.
通讯作者：
Tabassum, A.
DOI：
10.4103/0971-5916.193278
发表时间：
2016-07
期刊：
The Indian journal of medical research
影响因子：
--
作者：
Padmapriyadarsini C;Shobana M;Lakshmi M;Beena T;Swaminathan S
通讯作者：
Swaminathan S
DOI：
10.4103/0970-2113.95320
发表时间：
2012-04
期刊：
Lung India : official organ of Indian Chest Society
影响因子：
--
作者：
Azhar GS
通讯作者：
Azhar GS
影响因子：
1.4
作者：
Roy N;Basu M;Das S;Mandal A;Dutt D;Dasgupta S
通讯作者：
Dasgupta S