Diabetes and Its Cardiovascular Complications: Comprehensive Network and Systematic Analyses.
Diabetes and Its Cardiovascular Complications: Comprehensive Network and Systematic Analyses.
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DOI：
10.3389/fcvm.2022.841928
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发表时间：
2022
影响因子：
3.6
通讯作者：
Chen H
中科院分区：
文献类型：
--
作者：
Wu H;Norton V;Cui K;Zhu B;Bhattacharjee S;Lu YW;Wang B;Shan D;Wong S;Dong Y;Chan SL;Cowan D;Xu J;Bielenberg DR;Zhou C;Chen H
糖尿病是一个世界性的健康问题，通常伴有严重的并发症。目前还没有治愈糖尿病的方法，这些并发症的威胁是研究人员不断研究糖尿病的机制和治疗方法的原因。由于基因组学、表观基因组学、蛋白质组学和单细胞多组学研究的进步，在理解糖尿病的机制方面取得了相当大的进展。此外，对糖尿病与其他生理系统之间的关联的研究揭示了参与糖尿病发生和发展的潜在新途径和靶点。本文综述了近年来利用基因组学、表观基因组学、蛋白质组学和单细胞多组学等方法研究糖尿病发病机制的进展。它还将侧重于有关糖尿病和其他生物过程之间的关系的最新发现，以及糖尿病对几种病理状况的贡献的新发现。
Diabetes mellitus is a worldwide health problem that usually comes with severe complications. There is no cure for diabetes yet and the threat of these complications is what keeps researchers investigating mechanisms and treatments for diabetes mellitus. Due to advancements in genomics, epigenomics, proteomics, and single-cell multiomics research, considerable progress has been made toward understanding the mechanisms of diabetes mellitus. In addition, investigation of the association between diabetes and other physiological systems revealed potentially novel pathways and targets involved in the initiation and progress of diabetes. This review focuses on current advancements in studying the mechanisms of diabetes by using genomic, epigenomic, proteomic, and single-cell multiomic analysis methods. It will also focus on recent findings pertaining to the relationship between diabetes and other biological processes, and new findings on the contribution of diabetes to several pathological conditions.
DOI：
10.2337/cd21-0019
发表时间：
2021-10
期刊：
Clinical diabetes : a publication of the American Diabetes Association
影响因子：
--
作者：
Tay S;Abdulnabi S;Saffaf O;Harroun N;Yang C;Semenkovich CF;Zayed MA
通讯作者：
Zayed MA
影响因子：
3.7
作者：
Morrison T;Jones S;Causby RS;Thoirs K
通讯作者：
Thoirs K