The bioinorganic chemistry and associated immunology of chronic beryllium disease.
The bioinorganic chemistry and associated immunology of chronic beryllium disease.
复制标题
慢性铍病的生物无机化学和相关免疫学。
DOI：
10.1039/b718746g
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发表时间：
2008
期刊：
影响因子：
--
通讯作者：
Gnanakaran,S
中科院分区：
文献类型：
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作者：
Scott,BrianL;McCleskey,TMark;Chaudhary,Anu;Hong-Geller,Elizabeth;Gnanakaran,S
慢性铍病 (CBD) 是一种使人衰弱、无法治愈且往往致命的疾病，由吸入铍颗粒引起。现代世界中铍的使用量不断增加，从计算机到假牙等产品（2000 年美国使用了 390 吨铍）需要对这种疾病进行分子基础上的了解，以便预防和治疗 CBD。过去六年，我们在洛斯阿拉莫斯国家实验室采用生物无机化学和免疫学的多学科方法研究了 CBD 的分子基础。将讨论这项工作的结果，包括形态、吸入和溶解以及免疫学。
Chronic beryllium disease (CBD) is a debilitating, incurable, and often fatal disease that is caused by the inhalation of beryllium particulates. The growing use of beryllium in the modern world, in products ranging from computers to dental prosthetics (390 tons of beryllium in the US in the year 2000) necessitates a molecular based understanding of the disease in order to prevent and cure CBD. We have investigated the molecular basis of CBD at Los Alamos National Laboratory during the past six years, employing a multidisciplinary approach of bioinorganic chemistry and immunology. The results of this work, including speciation, inhalation and dissolution, and immunology will be discussed.