Right hemispheric dominance of inhibitory control: An event-related functional MRI study
Right hemispheric dominance of inhibitory control: An event-related functional MRI study
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DOI：
10.1073/pnas.96.14.8301
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发表时间：
1999-07-06
影响因子：
11.1
通讯作者：
Stein, EA
中科院分区：
文献类型：
--
作者：
Garavan, H;Ross, TJ;Stein, EA
正常的人类行为和认知依赖于一个人抑制不适当的想法、冲动和行为的能力。利用事件相关功能磁共振成像（fMRI）的时间和空间优势，以确定皮层区域，表现出短暂的变化后，抑制的优势运动反应的fMRI信号。事件相关功能磁共振成像设计的时间特异性也最大限度地减少了反应抑制错误的可能污染（即。例如，错误）和其他无关过程。确定的区域明显偏向右半球，包括额中回和额下回、额叶边缘区、前额叶和顶叶下叶。相反，传统的突出腹侧额叶区域的反应抑制，结果表明，反应抑制是由一个分布式的皮层网络。
Normal human behavior and cognition are reliant on a person's ability to inhibit inappropriate thoughts, impulses, and actions. The temporal and spatial advantages of event-related functional MRI (fMRI) were exploited to identify cortical regions that showed a transient change in fMRI signal after the withholding of a prepotent motor response. The temporal specificity of the event-related fMRI design also minimized possible contamination from response inhibition errors (i. e., commission errors) and other extraneous processes. Regions identified were strongly lateralized to the right hemisphere and included the middle and inferior frontal gyri, frontal limbic area, anterior insula, and inferior parietal lobe. Contrary to the prominence traditionally given to ventral frontal regions for response inhibition, the results suggest that response inhibition is accomplished by a distributed cortical network.