Minimal change disease in a patient receiving IFN-alpha therapy for chronic hepatitis C virus infection.
Minimal change disease in a patient receiving IFN-alpha therapy for chronic hepatitis C virus infection.
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因慢性丙型肝炎病毒感染而接受 IFN-α 治疗的患者出现微小病变。
DOI：
10.1089/10799900360520450
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发表时间：
2003
期刊：
影响因子：
--
通讯作者：
A. Pahsa
中科院分区：
文献类型：
--
作者：
U. Dizer;Can Murat Beker;I. Yavuz;M. Ortatatli;Volka Ozguven;A. Pahsa
慢性丙型肝炎病毒（HCV）感染与几种肝外综合征有关。与慢性HCV感染相关的肾脏疾病的主要类型是冷球蛋白血症或非冷球蛋白血症性膜增生性肾小球肾炎（MPGN）。干扰素-α（IFN-α）可促进或加重MPGN的发生。我们的病人是一个32岁的男子谁在1997年7月测试阳性丙型肝炎病毒。患者在另一家医疗中心接受IFN-α治疗6个月，因为他的肝活检显示慢性活动性肝炎。1998年12月，他向我们诊所申请进行随访检查。谷草转氨酶（AST）为44 U/L，丙氨酸转氨酶（ALT）为69 U/L。血清HCVRNA阳性，肝活检发现慢性HCV感染。IFN-α治疗（500万U/天）持续6个月以上。1999年5月，患者因足部和腿部水肿来到我们的综合诊所。我们检测到蛋白尿，血清胆固醇269 mg/dl，AST 50 U/L，ALT 41 U/L，血清总蛋白3.4 g/dl，血清白蛋白1.2 g/dl，阳性cryocellulin，尿蛋白9.84 g/d。怀疑为冷球蛋白血症性MPGN，并进行了肾活检，诊断为微小病变病（MCD）。
Chronic hepatitis C virus (HCV) infection is associated with several extrahepatic syndromes. The principal types of renal disorders associated with chronic HCV infection are cryoglobulinemia or noncryoglobulinemic membranoproliferative glomerulonephritis (MPGN). Interferon-alpha (IFN-alpha) may precipitate or exacerbate the occurrence of MPGN. Our patient was a 32-year-old man who tested positive for HCV in July 1997. The patient was treated with IFN-alpha in another medical center for 6 months because his liver biopsy showed chronic active hepatitis. In December 1998, he applied to our clinic for a follow-up examination. The level of aspartate aminotransferase (AST) was 44 U/L, and that of alanine aminotransferase (ALT) was 69 U/L. HCV RNA was positive in serum, and chronic HCV infection was detected by liver biopsy. IFN-alpha therapy (5 million U/day) was administered for 6 months longer. In May 1999, the patient came to our polyclinic with edema of the feet and legs. We detected proteinuria, serum cholesterol of 269 mg/dl, AST of 50 U/L, ALT of 41 U/L, serum total protein of 3.4 g/dl, serum albumin of 1.2 g/dl, positive cryoglobulin, and urine protein of 9.84 g/day. Cryoglobulinemic MPGN was suspected and kidney biopsy was performed, resulting in a diagnosis of minimal change disease (MCD).
丙型肝炎的病理生物学作用。
DOI：
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发表时间：
1995
期刊：
Journal of hepatology.
影响因子：
--
作者：
Gerber,MA
通讯作者：
Gerber,MA
通过荧光原位杂交检测到染色体大小对伽马辐射引起的畸变水平的影响。
DOI：
10.1159/000133807
发表时间：
1994
期刊：
Cytogenetics and cell genetics
影响因子：
--
作者：
Pandita,TK;Gregoire,V;Dhingra,K;Hittelman,WN
通讯作者：
Hittelman,WN