fMRI: a new tool for the in vivo localization of drug actions in the brain.
fMRI: a new tool for the in vivo localization of drug actions in the brain.
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fMRI：一种用于大脑中药物作用体内定位的新工具。
DOI：
10.1093/jat/25.5.419
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发表时间：
2001
影响因子：
2.5
通讯作者：
Stein,EA
中科院分区：
文献类型：
--
作者：
Stein,EA
功能磁共振成像（fMRI）是一种新兴的非侵入性神经成像工具，已广泛应用于感觉、运动控制和认知心理学等领域的问题。直到最近，它才被应用于了解药物在人类中枢神经系统内的作用位点和机制。然而，在这样做的过程中，由于存在从潜在神经元活动产生 fMRI 信号的独特转导机制（生理和生物物理），因此必须解决围绕该技术的一系列新问题和担忧。实验设计和控制问题在执行功能磁共振成像药理学方案和信号解释中变得至关重要。考虑到这些警告，随着有关大脑生理学和神经药理学机制的新问题首次得到解决，功能磁共振成像药物的使用在短期内可能会大大增加。给出了使用尼古丁和可卡因作为典型药物的例子。
Functional magnetic resonance imaging (fMRI), a still-emerging, non-invasive neuroimaging tool, has been applied to a wide range of questions in sensory, motor control, and cognitive psychology. Only more recently has it been applied to understand the sites and mechanisms of action of pharmacological agents within the human CNS. However, in so doing, a new set of problems and concerns surrounding the technique must be addressed because of the unique transduction mechanisms (both physiological and biophysical) that exist to produce the fMRI signal from the underlying neuronal activity. Experimental design and control issues become paramount in performing fMRI pharmacological protocols and in signal interpretation. With these caveats, the use of pharmacological agents with fMRI is likely to greatly increase in the near term as new questions about both brain physiology and neuropharmacological mechanisms become addressable for the first time. Examples are given using nicotine and cocaine as a prototypical agents.