Case-control Studies on the Relationship between Onchocerciasis and Epilepsy: Systematic Review and Meta-analysis
Case-control Studies on the Relationship between Onchocerciasis and Epilepsy: Systematic Review and Meta-analysis
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DOI：
10.1371/journal.pntd.0002147
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发表时间：
2013-03-01
影响因子：
3.8
通讯作者：
Boussinesq, Michel
中科院分区：
文献类型：
--
作者：
Kaiser, Christoph;Pion, Sebastien D. S.;Boussinesq, Michel
目的：对所有关于盘尾丝虫病与癫痫关系的病例对照研究进行系统回顾和荟萃分析。由于居住地区的年龄和盘尾丝虫病流行程度是感染的主要决定因素，因此进行了额外的分析，但仅限于控制这些混杂因素的研究。数据来源：医学数据库，“利摩日神经流行病学和热带神经病学研究所非洲神经病学数据库”，相关文章参考书目，商业搜索引擎，截至2012年5月。方法：我们检索了检查癫痫（PWE）和非癫痫（PWOE）患者盘尾丝虫感染状况的研究，这些研究提供了适用于使用随机效应模型计算合并优势比（ORp）和/或标准化平均差异（SMD）的数据。结果：11项研究提供了定性皮肤活检诊断盘尾丝虫病的资料。对876例PWE和4712例PWOE的总样本进行综合分析，ORp为2.49(95%置信区间（95% CI）： 1.61-3.86, p
Objective: A systematic review and meta-analysis of all available case-control studies on the relationship between onchocerciasis and epilepsy. Because age and level of onchocerciasis endemicity in the area of residence are major determinants for infection, an additional analysis was performed, restricted to studies achieving control of these confounding factors.Data sources: Medical databases, the "African Neurology Database, Institute of Neuroepidemiology and Tropical Neurology, Limoges," reference lists of relevant articles, commercial search engines, up to May 2012.Methods: We searched for studies examining infection status with Onchocerca volvulus in persons with epilepsy (PWE) and without epilepsy (PWOE) providing data suitable for the calculation of pooled odds ratios (ORp) and/or standardized mean differences (SMD) using random-effects models.Results: Eleven studies providing data of qualitative skin biopsies for diagnosis of onchocerciasis were identified. Combined analysis on the total sample of 876 PWE and 4712 PWOE resulted in an ORp of 2.49 (95% confidence interval (95% CI): 1.61-3.86, p