PET pharmacokinetic analysis to estimate boron concentration in tumor and brain as a guide to plan BNCT for malignant cerebral glioma
PET pharmacokinetic analysis to estimate boron concentration in tumor and brain as a guide to plan BNCT for malignant cerebral glioma
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DOI：
10.1016/j.apradiso.2009.03.061
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发表时间：
2009-07-01
影响因子：
1.6
通讯作者：
Ohno, Kikuo
中科院分区：
文献类型：
--
作者：
Nariai, Tadashi;Ishiwata, Kiichi;Ohno, Kikuo
为了规划恶性脑胶质瘤患者的最佳BNCT，估计肿瘤组织中硼浓度与周围正常脑的硼浓度之比（硼的T/N比）很重要。我们报道了一种基于氨基酸探针药代动力学分析的正电子发射断层扫描（PET）成像方法来估计组织硼浓度的T/N比。方法：12例脑恶性胶质瘤患者在静脉注射（18）f -硼-苯-丙氨酸（FBPA）后，行60 min动态PET脑扫描，并定时动脉采血。利用该扫描获得的动力学参数，利用龙格-库塔算法模拟BNCT中持续输注BPA 1小时引起的硼浓度T/N比。（11）同时进行国际PET中心常用的脑肿瘤成像工具c -蛋氨酸（MET） PET扫描，比较FBPA与MET的图像特征。结果：在所有患者中，FBPA和MET获得的PET胶质瘤图像几乎相同。恒定输注BPA 1小时后组织硼浓度T/N比值、静态条件下FBPA T/N比值、静态条件下MET T/N比值呈显著线性相关。结论：BNCT期间持续输注BPA获得的硼浓度T/N比可通过FBPA PET扫描估计。这一比例也可以通过pet成像来估计。由于许多临床PET中心都可以进行MET-PET研究，因此可以通过MET-PET图像选择BNCT的候选者。可以通过FBPA PET的静态图像来精确规划BNCT。利用氨基酸探针进行PET成像可能有助于确定BNCT在恶性胶质瘤患者中的适当应用。2009爱思唯尔有限公司版权所有。
Introduction: To plan the optimal BNCT for patients with malignant cerebral glioma, estimation of the ratio of boron concentration in tumor tissue against that in the surrounding normal brain (T/N ratio of boron) is important. We report a positron emission tomography (PET) imaging method to estimate T/N ratio of tissue boron concentration based on pharmacokinetic analysis of amino acid probes.Methods: Twelve patients with cerebral malignant glioma underwent 60 min dynamic PET scanning of brain after bolus injection of (18)F-borono-phenyl-alanine (FBPA) with timed arterial blood sampling. Using kinetic parameter obtained by this scan, T/N ratio of boron concentration elicited by one-hour constant infusion of BPA, as performed in BNCT, was simulated on Runge-Kutta algorithm. (11)C-methionine (MET) PET scan, which is commonly used in worldwide PET center as brain tumor imaging tool, was also performed on the same day to compare the image characteristics of FBPA and that of MET.Result: PET glioma images obtained with FBPA and MET are almost identical in all patients by visual inspection. Estimated T/N ratio of tissue boron concentration after one-hour constant infusion of BPA, T/N ratio of FBPA on static condition, and T/N ratio of MET on static condition showed significant linear correlation between each other.Conclusion: T/N ratio of boron concentration that is obtained by constant infusion of BPA during BNCT can be estimated by FBPA PET scan. This ratio can also be estimated by MET-PET imaging. As MET-PET study is available in many clinical PET center, selection of candidates for BNCT may be possible by MET-PET images. Accurate planning of BNCT may be performed by static images of FBPA PET. Use of PET imaging with amino acid probes may contribute very much to establish an appropriate application of BNCT for patients with malignant glioma. (C) 2009 Elsevier Ltd. All rights reserved.