HEREDITARY DIABETES IN GENETICALLY OBESE MICE
HEREDITARY DIABETES IN GENETICALLY OBESE MICE
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DOI：
10.1126/science.113.2948.746
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发表时间：
1951-01-01
期刊：
影响因子：
56.9
通讯作者：
DICKIE, MM
中科院分区：
文献类型：
--
作者：
MAYER, J;BATES, MW;DICKIE, MM
* The figures after the+ signs represent standard deviations. three diets in proper amounts: choline, thiamine, pyridoxine, riboflavin, niacin, calcium pantothenate, p-aminobenzoic acid, a-tocopherol, and inositol. These diets were placed in separate 10-cc beakers disposed on the inside of V-shaped racks, with a slit opening allowing the animals to eat, but preventing them from either spilling or contaminating the diet. Food and water were given ad lib. Food cups were weighed daily. The animals were on experiment an average of 18 days. The results, in grams, of diets I, II, and III eaten by obese and nonobese animals daily, as well as total average daily food intakes, are given in Table 1. Total daily calories, as well as percentage derived from carbohydrate, protein, and fat, are given in Table 2.It will immediately be apparent that very marked differences were found between obese and nonobese animals. First, evidently, obese animals ate significantly more than nonobese animals (P= 0.03). Although the average difference of 5 cal/day between obese and nonobese animals may not appear sufficient to account for the differences in weight observed, it may be useful to recall that in 30 days a difference of 5 cal daily, with a maximum thermochemical efficiency of 24%(3), could represent up to 4 g of depot fat alone. If the difference in body composition com-prises proteins and associated water, the difference in body weight could in theoryrun up to four times this value. Second, there were equally marked differences in the proportion of the calories derived from fat, protein, and carbohydrates. The obese animals ate proportionately more fat (P< 0.0001), less protein (P= 0.03), and less carbohydrate (P= 0.007) than the nonobese animals, with the differences in fat and carbohydrate particularly striking. These in turn led to two important considerations. First, the increase in fat and decrease in carbohydrate intake could be easily correlated with the" glucostatic" theory ofthe regulation of food intake (4). Second, the type of diet selected by the obese animals was reminiscent of diets restricted in carbohydrate often used in the dietary
