T cell receptors and T cell development.
T cell receptors and T cell development.
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T 细胞受体和 T 细胞发育。
DOI：
10.1007/978-3-642-80057-3_5
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发表时间：
1996
影响因子：
--
通讯作者：
Cooper,MD
中科院分区：
文献类型：
--
作者：
Chen,CH;Six,A;Kubota,T;Tsuji,S;Kong,FK;Göbel,TW;Cooper,MD
鸟类为研究早期发育提供了一个有价值的模型系统。对鸡免疫系统发育和功能的研究为免疫学中的一些核心原则做出了贡献。这些包括：（1）在移植物抗宿主（GVH）反应中淋巴细胞的同种异体识别（Simonsen 1985），（2）免疫活性淋巴细胞的克隆反应性（Burnet 1957），（3）T和B细胞的单独分化途径，它们在免疫应答中协同作用（Cooperet al.1965），（4）淋巴系和髓系的造血干细胞来源（MooreandOwen 1965）;（5）胸腺祖细胞的发育迁移波（Le Douarin 1978），（6）携带IgM的B淋巴细胞的免疫球蛋白（IG）同种型转换（Kincadeet al.1970; KincadeandCooper 1973），和（7）通过基因转换的B细胞库的体细胞多样化（Kincaudet al.1987; KincadeandNeiman 1987）。
Birds provide a valuable model system for the study of early development. Studies of immune system development and function in chickens have contributed to some of the central tenets in immunology. These include:(1) allorecognition by lymphocytes in graft-vs-host (GVH) reactions (Simonsen1985), (2) clonal reactivity of immunocompetent lymphocytes (Burnet1957), (3) the separate differentiation pathways of T and B cells which cooperate in immune responses (Cooperet al. 1965), (4) hematopoietic stem cell origin of both lymphoid and myeloid lineages (MooreandOwen1965), (5) the developmental migratory waves of thymocyte progenitors (Le Douarin1978), (6) immunoglobulin (Ig) isotype switching by IgM-bearing B lymphocytes (Kincadeet al. 1970;KincadeandCooper1973), and (7) somatic diversification of the B cell repertoire by gene conversion (Reynaudet al. 1987;ThompsonandNeiman1987).