Clinical observation of blood loss reduced by tranexamic acid during and after caesarian section: a multi-center, randomized trial
Clinical observation of blood loss reduced by tranexamic acid during and after caesarian section: a multi-center, randomized trial
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DOI：
10.1016/s0301-2115(03)00287-2
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发表时间：
2004-02-10
期刊：
影响因子：
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通讯作者：
Tatsumoto, K
中科院分区：
文献类型：
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作者：
Gai, MY;Wu, LF;Tatsumoto, K
目的：探讨氨甲环酸在剖宫产术中的有效性和安全性。研究设计：前瞻性、随机、病例对照临床试验。人群：180名初产妇随机分为两组。研究组有91名妇女在CS之前立即服用氨甲环酸，而对照组有89名妇女没有服用。方法：分两期采血。第一阶段为胎盘娩出至CS结束，第二阶段为CS结束至产后2h。测量两组患者的血流量并进行比较。检测两组患者全血细胞计数、尿检、肝肾功能、凝血酶原时间及活性。结果：氨甲环酸显著降低了CS结束至产后2 h的血流量：研究组为42.75 +/- 40.45 ml，对照组为73.98 +/- 77.09 ml （P = 0.001）。研究组胎盘分娩至产后2 h总血量为351.57 +/- 148.20 ml，对照组为439.36 +/- 191.48 ml （P = 0.002）。两组均无并发症或副作用。结论：氨甲环酸在统计学上降低了产后2小时胎盘出血的程度，其使用与任何副作用或并发症无关。因此，氨甲环酸可以安全有效地用于减少CS引起的出血。2003爱思唯尔爱尔兰有限公司版权所有。
Objectives: To explore the efficacy and safety of tranexamic acid at caesarian section (CS). Study design: Prospective, randomized, casecontrolled clinical trial. Population: One hundred and eighty primiparas were randomized into two groups. The study group, 91 women, received tranexamic acid immediately before CS whereas the control group, 89 women did not. Method: Blood was collected during two periods. The first period was from placental delivery to the end of CS and the second was from the end of CS to 2 h postpartum. The quantity of blood was measured and compared between the two groups. Complete blood count, urinalysis, liver and renal function, prothrombin time and activity, were tested in the two groups. Results: Tranexamic acid significantly reduced the quantity of blood from the end of CS to 2 h postpartum: 42.75 +/- 40.45 ml in the study group versus 73.98 +/- 77.09 ml in the control group (P = 0.001). It also significantly reduced the quantity of total blood from placental delivery to 2 h postpartum: 351.57 +/- 148.20 ml in the study group, 439.36 +/- 191.48 ml in the control group (P = 0.002). No complications or side effects were reported in either group. Conclusions: Tranexamic acid statistically reduces the extent of bleeding from placental delivery to 2 h postpartum and its use was not associated with any side effects or complications. Thus, tranexamic acid can be used safely and effectively to reduce bleeding resulting from CS. (C) 2003 Elsevier Ireland Ltd. All rights reserved.