The biological function and clinical utilization of CD147 in human diseases: a review of the current scientific literature.
The biological function and clinical utilization of CD147 in human diseases: a review of the current scientific literature.
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CD147 在人类疾病中的生物学功能和临床应用：当前科学文献综述
DOI：
10.3390/ijms151017411
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发表时间：
2014-09-29
影响因子：
5.6
通讯作者：
Zhou L
中科院分区：
文献类型：
--
作者：
Xiong L;Edwards CK 3rd;Zhou L
CD147或EMMPRIN是人类免疫球蛋白超家族的成员。它在人类肿瘤中广泛表达，并通过刺激基质金属蛋白酶（MMPs）和细胞因子的分泌在许多癌症的进展中发挥核心作用。CD147调节细胞增殖、凋亡和肿瘤细胞迁移、转移和分化，特别是在缺氧条件下。CD147对许多器官系统也很重要。本文就CD147的发现、表征、分子结构、生物学功能及其在人类生理和病理过程中的调控机制作一综述。特别是，最近的研究表明，CD147不仅可以作为活化的调节性T细胞的表型标志物，而且可以作为早期疾病的潜在诊断标志物。此外，CD147被认为是肝细胞癌（HCC）和其他癌症的有效治疗靶点，并且使用CD147定向的单克隆抗体在HCC治疗中已经取得了令人兴奋的临床进展。
CD147 or EMMPRIN is a member of the immunoglobulin superfamily in humans. It is widely expressed in human tumors and plays a central role in the progression of many cancers by stimulating the secretion of matrix metalloproteinases (MMPs) and cytokines. CD147 regulates cell proliferation, apoptosis, and tumor cell migration, metastasis and differentiation, especially under hypoxic conditions. CD147 is also important to many organ systems. This review will provide a detailed overview of the discovery, characterization, molecular structure, diverse biological functions and regulatory mechanisms of CD147 in human physiological and pathological processes. In particular, recent studies have demonstrated the potential application of CD147 not only as a phenotypic marker of activated regulatory T cells but also as a potential diagnostic marker for early-stage disease. Moreover, CD147 is recognized as an effective therapeutic target for hepatocellular carcinoma (HCC) and other cancers, and exciting clinical progress has been made in HCC treatment using CD147-directed monoclonal antibodies.
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DOI：
10.1016/j.bbrc.2012.02.049
发表时间：
2012-03-16
影响因子：
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