Identifying biological themes within lists of genes with EASE.

Identifying biological themes within lists of genes with EASE.
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DOI:
10.1186/gb-2003-4-10-r70
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发表时间:
2003
期刊:
影响因子:
12.3
通讯作者:
Lempicki RA
Lempicki RA
中科院分区:
生物学1区
文献类型:
--
作者:
Hosack DA;Dennis G Jr;Sherman BT;Lane HC;Lempicki RA

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EASE是一款可定制的软件应用程序,用于对基因列表进行快速生物学解释,这些基因列表来自微阵列、蛋白质组学、SAGE和其他高通量基因组数据的分析。EASE是一款可定制的软件应用程序,用于对基因列表进行快速生物学解释,这些基因列表来自微阵列、蛋白质组学、SAGE和其他高通量基因组数据的分析。EASE返回的生物学主题概括了先前发表的基因列表中人工确定的主题,并且对各种归一化、强度计算和基因统计选择方法具有鲁棒性。EASE是将功能基因组学研究结果从“基因”快速转换为“主题”的强大工具。
EASE is a customizable software application for rapid biological interpretation of gene lists that result from the analysis of microarray, proteomics, SAGE and other high-throughput genomic data. EASE is a customizable software application for rapid biological interpretation of gene lists that result from the analysis of microarray, proteomics, SAGE and other high-throughput genomic data. The biological themes returned by EASE recapitulate manually determined themes in previously published gene lists and are robust to varying methods of normalization, intensity calculation and statistical selection of genes. EASE is a powerful tool for rapidly converting the results of functional genomics studies from 'genes' to 'themes'.
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