LC-MS-based metabolomics: an update.
LC-MS-based metabolomics: an update.
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DOI：
10.1007/s00204-014-1234-6
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发表时间：
2014-08
影响因子：
6.1
通讯作者：
Gonzalez FJ
中科院分区：
文献类型：
--
作者：
Fang ZZ;Gonzalez FJ
基于液相色谱-质谱（LC-MS）的代谢组学可以在多个研究领域产生重大影响，特别是当与其他技术结合时，如稳定同位素示踪剂和转基因小鼠。本文综述了近年来代谢组学技术在外源性物质代谢和毒性研究以及疾病发病机制和治疗方面的应用。代谢组学已被用于研究芳香族碳氢化合物受体拮抗剂诺斯卡品的代谢，并确定利福平和异烟肼、三氯乙烯和吉非罗齐的肝毒性机制。还将讨论以代谢组学为基础的炎症性肠病、酒精诱导的肝病、非酒精性脂肪性肝炎和法尼醇X受体信号通路为基础的治疗靶点发现的发病机制。代谢组学技术的局限性，如样品制备和缺乏LC-MS数据库和代谢物标准，需要解决，以改善和扩大代谢组学研究的应用。
Liquid chromatography–mass spectrometry (LC–MS)-based metabolomics can have a major impact in multiple research fields, especially when combined with other technologies, such as stable isotope tracers and genetically modified mice. This review highlights recent applications of metabolomic technology in the study of xenobiotic metabolism and toxicity, and the understanding of disease pathogenesis and therapeutics. Metabolomics has been employed to study metabolism of noscapine, an aryl hydro-carbon receptor antagonist, and to determine the mechanisms of liver toxicities of rifampicin and isoniazid, trichloroethylene, and gemfibrozil. Metabolomics-based insights into the pathogenesis of inflammatory bowel disease, alco-hol-induced liver diseases, non-alcoholic steatohepatitis, and farnesoid X receptor signaling pathway-based thera-peutic target discovery will also be discussed. Limitations in metabolomics technology such as sample preparation and lack of LC–MS databases and metabolite standards, need to be resolved in order to improve and broaden the application of metabolomic studies.
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DOI：
10.1073/pnas.1319582110
发表时间：
2013-12-10
影响因子：
11.1
作者：
Jansen, Robert S.;Kucukosmanoglu, Asli;van de Wetering, Koen
通讯作者：
van de Wetering, Koen
影响因子：
6.1
作者：
Fang ZZ;Krausz KW;Tanaka N;Li F;Qu A;Idle JR;Gonzalez FJ
通讯作者：
Gonzalez FJ
影响因子：
7.3
作者：
Fang ZZ;Krausz KW;Nagaoka K;Tanaka N;Gowda K;Amin SG;Perdew GH;Gonzalez FJ
通讯作者：
Gonzalez FJ
DOI：
10.1007/bf03190592
发表时间：
2004-07-01
影响因子：
1.9
作者：
Aneja, R;Katyal, A;Chandra, R
通讯作者：
Chandra, R
影响因子：
4.4
作者：
Evans CR;Karnovsky A;Kovach MA;Standiford TJ;Burant CF;Stringer KA
通讯作者：
Stringer KA