Females secrete growth hormone with more process irregularity than males in both humans and rats
Females secrete growth hormone with more process irregularity than males in both humans and rats
复制标题
DOI：
10.1152/ajpendo.1996.270.1.e107
复制
发表时间：
1996-01-01
影响因子：
5.1
通讯作者：
Veldhuis, JD
中科院分区：
文献类型：
--
作者：
Pincus, SM;Gevers, EF;Veldhuis, JD
在人类中，女性的血清生长激素（GH）浓度明显高于男性，但这种性别差异背后的神经内分泌机制尚不清楚。我们比较了正常的情节生长激素分泌的男性和女性在三个不同的设置：两个人类研究采用完全不同的检测技术（免疫放射分析和高灵敏度免疫荧光法）和大鼠的研究。为了量化数据中的规律性，我们利用了近似熵（ApEn），这是一种与尺度和模型无关的统计量。在每项研究中，女性在GH浓度系列中表现出比男性更大的统计学不规则性（每项人体研究P < 10（-3），大鼠研究P < 10（-6）），这意味着男性和女性的GH分泌量和模式受到不同的调节。规律性比较表明大鼠研究中完全性别分离（100%特异性和灵敏度），免疫荧光测定研究中几乎完全分离。这些结果的一致性和统计学意义表明，这种性别差异可能广泛基于高等动物，这可能很容易客观地评估分析的近似熵。
In humans, serum growth hormone (GH) concentrations are significantly higher in women than in men, but the neuroendocrine mechanisms that underlie such gender differences are not known. We compared normal episodic GH secretion in males and females in three distinct settings: two human studies employing quite different assay techniques (immunoradiometric assay and a high-sensitivity immunofluorimetric method) and a rat study. To quantify the amount of regularity in data, we utilized approximate entropy (ApEn), a scale- and model-independent statistic. In each study, females exhibited significantly greater statistical irregularity in GH concentration series than their male counterparts (P < 10(-3) for each human study, P < 10(-6) for the rat study), implying that mass and mode of GH secretion are regulated differently in males and females. The regularity comparisons indicated complete gender separation (100% specificity and sensitivity) for the rat study and nearly complete separation for the immunofluorimetric assay study. The consistency and statistical significance of these findings suggest that this gender difference may be broadly based within higher animals and that this may be readily evaluated objectively by analysis of ApEn.