Atlas-based investigation of human brain tissue microstructural spatial heterogeneity and interplay between transverse relaxation time and radial diffusivity.
Atlas-based investigation of human brain tissue microstructural spatial heterogeneity and interplay between transverse relaxation time and radial diffusivity.
复制标题
基于图集的人类脑组织微观结构空间异质性以及横向弛豫时间和径向扩散率之间的相互作用的研究。
DOI：
10.1016/j.neuroimage.2011.05.063
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发表时间：
2011
期刊：
影响因子：
5.7
通讯作者：
Hasan,KhaderM
中科院分区：
文献类型：
--
作者：
Walimuni,IndikaS;Hasan,KhaderM
使用磁共振成像（MRI）获得的微观结构指标，如横向弛豫时间和径向扩散率已被用作人脑组织完整性的体内标记。考虑到这些参数对一些常见的生物物理贡献者及其结构和空间异质性的敏感性，我们假设这些变量之间存在强的区域间和区域内关联，为横向弛豫时间和径向扩散率之间可能的相互作用提供证据。为了验证我们的假设，我们获得了高分辨率的解剖T1加权数据，并将其与T2弛豫和扩散张量成像（DTI）数据的健康成人队列。使用FreeSurfer对解剖数据进行分组，然后与T2和DTI图进行共对齐和融合。我们的数据揭示了横向弛豫和径向扩散率之间的一些关联，这可能有助于对测量的MRI指标的生物物理贡献者的解释和建模。
Microstructural metrics obtained using magnetic resonance imaging (MRI) such as transverse relaxation time and radial diffusivity have been used as in vivo markers of human brain tissue integrity. Considering the sensitivity of these parameters to some common biophysical contributors and their structural and spatial heterogeneity, we hypothesized that strong inter and intra-regional associations exist between these variables providing evidence to possible interplay between transverse relaxation time and radial diffusivity. To validate our hypothesis we obtained high resolution anatomical T1-weighted data and fused it with T2-relaxometry and diffusion tensor imaging (DTI) data on a cohort of healthy adults. The anatomical data were parcellated using FreeSurfer and then coaligned and fused with the T2 and DTI maps. Our data reveal some association between transverse relaxation and radial diffusivity that may help toward the interpretation and modeling of the biophysical contributors to the measured MRI metrics.