TRANSFORMING GROWTH-FACTOR-BETA-2 IN LABIAL SALIVARY-GLANDS IN SJOGRENS-SYNDROME
TRANSFORMING GROWTH-FACTOR-BETA-2 IN LABIAL SALIVARY-GLANDS IN SJOGRENS-SYNDROME
复制标题
DOI：
10.1136/ard.54.9.744
复制
发表时间：
1995-09-01
影响因子：
27.4
通讯作者：
MALMSTROM, M
中科院分区：
文献类型：
--
作者：
KOSKI, H;KONTTINEN, YT;MALMSTROM, M
比较转化生长因子β的分布和数量方法采用过氧化物酶-抗过氧化物酶染色法对干燥综合征（SS）患者（n = 10）和健康对照者（n = 6）的唇唾液腺（LSG）进行TGF β 2标记，结果在SS和健康对照组的所有LSG中，TGF β 2均见于毛细血管内皮细胞、囊膜和间质成纤维细胞中。在SS的LSG中，在炎性细胞灶的一些淋巴细胞和纤维化区域的成纤维细胞中也发现了TGF β 2。TGF β 2染色指数（μ m（2）/mm（2）组织）在SS中大于对照LSG（3670（SEM 430）v 2061（176）; p < 0.01），原发性和继发性SS之间无差异结论TGF β 2的定位和表达水平表明其参与局部组织纤维化，并可能反映免疫抑制的尝试。
Objective-To compare the distribution and the amount of transforming growth factor beta (TGF beta) in labial salivary glands (LSG) in patients with Sjogren's syndrome (SS) and healthy controls.Methods-LSG from SS patients (n = 10) and healthy controls (n = 6) were labelled with peroxidase-antiperoxidase staining for TGF beta 2, which was quantitated in image analysis using Video Interactive Display System software.Results-In all LSGs in SS and healthy controls, TGF beta 2 was found in endothelial cells of the capillaries and in the capsular and stromal fibroblasts. In LSGs in SS, TGF beta 2 was also found in some lymphocytes in the inflammatory cell foci and in fibroblasts in fibrotic areas. The TGF beta 2 staining index (mu m(2)/mm(2) tissue) was greater in SS than in control LSGs (3670 (SEM 430) v 2061 (176); p < 0.01), with no difference between the primary and secondary forms of SS (p > 0.05).Conclusion-The localisation and the level of expression of TGF beta 2 indicate its involvement in local tissue fibrosis, and may reflect attempts at immunosuppression.