The diagnostic and prognostic value of interleukin-6 in patients with soft tissue sarcomas.
The diagnostic and prognostic value of interleukin-6 in patients with soft tissue sarcomas.
复制标题
白介素-6在软组织肉瘤患者中的诊断和预后价值。
DOI：
10.1038/s41598-017-08781-6
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发表时间：
2017-08-29
影响因子：
4.6
通讯作者：
Sudo A
中科院分区：
文献类型：
--
作者：
Hagi T;Nakamura T;Iino T;Matsubara T;Asanuma K;Matsumine A;Sudo A
全身性炎症的存在已被报道与软组织肉瘤（STS）患者的预后不良有关。细胞因子白细胞介素-6（IL-6）对肿瘤微环境中的各种细胞类型具有多效性作用。本研究的目的是确定血清IL-6水平是否可用于假设良性软组织肿瘤从STS的分化，并调查IL-6的生存和肿瘤学事件的STS患者的可能价值。回顾性分析99例手术切除患者的病历资料。STS患者血清IL-6水平（中位数：9.04 pg/ml）显著高于良性软组织肿瘤患者（3.31 pg/ml）。我们的分析证实肿瘤大小和IL-6水平是STS诊断的重要预测因子。接下来，我们研究了59例STS患者的IL-6水平与生存率之间的关系。C反应蛋白水平、血红蛋白水平和肿瘤分级与IL-6水平密切相关。肿瘤分级和IL-6水平仍然是影响生存和无事件生存的重要因素。我们认为，IL-6水平的测量可能是一个有用的方法，用于确定患者谁是在STS和肿瘤相关死亡的高风险。
The presence of systemic inflammation has been reported to be associated with poor prognosis in patients with soft tissue sarcoma (STS). The cytokine interleukin-6 (IL-6) has pleiotropic effects on various cell types in the tumor microenvironment. The aim of the present study was to determine whether serum IL-6 levels could be useful to assume the differentiation of benign soft tissue tumors from STS and to investigate the possible value of IL-6 for survival and oncological events in patients with STS. The medical records of 99 patients who underwent surgical resection were retrospectively reviewed. Serum IL-6 levels (median: 9.04 pg/ml) in patients with STS were statistically higher than those (3.31 pg/ml) in patients with benign soft tissue tumors. Our analyses confirmed that tumor size and IL-6 level were significant predictors of STS diagnosis. Next, we examined the relationship between IL-6 levels and survival in the 59 patients with STS. C-reactive protein levels, hemoglobin levels, and tumor grade were strongly correlated with IL-6 levels. Tumor grade and IL-6 level remained significant factors for survival and event-free survival. We suggest that measurement of IL-6 levels may be a useful method for identifying patients who are at a high risk of STS and tumor-related death.
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影响因子：
45.3
作者：
Weitz, J;Antonescu, CR;Brennan, MF
通讯作者：
Brennan, MF
影响因子：
6.2
作者：
Duffy, Sonia A.;Taylor, Jeremy M. G.;Teknos, Theodoros N.
通讯作者：
Teknos, Theodoros N.
影响因子：
45.3
作者：
Coindre, JM;Terrier, P;Contesso, G
通讯作者：
Contesso, G
影响因子：
5.7
作者：
Fukuyama, Takashi;Ichiki, Yoshinobu;Yasumoto, Kosei
通讯作者：
Yasumoto, Kosei
影响因子：
4.5
作者：
Lamb, Gavin W. A.;McArdle, Peter A.;McMillan, Donald C.
通讯作者：
McMillan, Donald C.