Biocompatibility: Bioengineering aspects
Biocompatibility: Bioengineering aspects
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DOI：
10.3233/bme-120738
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发表时间：
2013-01-01
影响因子：
1
通讯作者：
Nose, Yukihiko
中科院分区：
文献类型：
--
作者：
Murabayashi, Shun;Nose, Yukihiko
生物工程师为生物相容性研究做出了贡献。许多材料已被设计，合成和表征使用各种分析仪器。材料的血液相容性研究主要集中在血液-材料界面反应。尽管已经积累了大量关于这种局部反应的信息，但对生物相容性的理解仍然有限。需要一种更加全球化的研究方法。一种新的方法来理解生物相容性的建议和讨论。强调三点：身体防御系统内的相互作用及其对血液-物质反应的影响;局部反应诱导全身反应，然后影响血液-物质相互作用;局部反应和全身反应之间相互作用的时间顺序。建立合理的生物相容性研究方法是生物相容性研究的重要内容。
Bioengineers have contributed to biocompatibility research. Many materials have been designed, synthesized and characterized by use of various analytical instruments. The blood compatibility of materials has been studied by focusing on the blood-material interfacial reactions. Although much information has been accumulated regarding such local reactions, understanding of biocompatibility is still limited. A more global approach to study is needed. A new approach to understanding biocompatibility is proposed and discussed. Three points are stressed: interaction within body's defense system and its effect on blood-material reactions; induction of a systemic reaction by a local reaction, which then affects the blood-material interaction; the time sequence of such interactions between local and systemic reactions. To establish a logical approach to study biocompatibility is most important at this moment for the future progress in biocompatibility research.