Lifestyle determinants of serum insulin-like growth-factor-I (IGF-I), C-peptide and hormone binding protein levels in British women
Lifestyle determinants of serum insulin-like growth-factor-I (IGF-I), C-peptide and hormone binding protein levels in British women
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DOI：
10.1023/a:1022518321634
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发表时间：
2003-02-01
影响因子：
2.3
通讯作者：
Key, TJ
中科院分区：
文献类型：
--
作者：
Allen, NE;Appleby, PN;Key, TJ
目的：本研究旨在确定胰岛素样生长因子-I（IGF-I）及其主要结合蛋白（IGFBPs）、C肽和性激素结合球蛋白（SHBG）的生活方式决定因素，以帮助阐明生活方式因素可能影响癌症风险的机制。方法：这项研究是基于292名年龄在20-70岁之间的英国妇女的样本，他们的生活方式特征使用自填式问卷进行评估，他们的血清激素浓度使用免疫测定法进行测量。年龄是IGF-I和IGFBP水平的重要决定因素;与20-24岁的女性相比，65-70岁的女性IGF-I和IGFBP-3浓度显著降低，IGFBP-1和IGFBP-2浓度显著升高。体重指数（BMI）与IGF-I的相关性并不强，尽管BMI为26-27.9 kg/m2的女性与两个瘦型（BMI）女性相比，IGF-I浓度较高
Objective: This study aims to identify the lifestyle determinants of insulin-like growth factor-I (IGF-I) and its main binding proteins (IGFBPs), C-peptide, and sex hormone-binding globulin (SHBG) to help elucidate the mechanism through which lifestyle factors may affect cancer risk.Methods: This study is based on a sample of 292 British women, aged 20-70 years, whose lifestyle characteristics were assessed using a self-administered questionnaire and whose serum hormone concentrations were measured using immunoassays.Results: Age was a strong determinant of both IGF-I and IGFBP levels; women aged 65-70 years had significantly lower IGF-I and IGFBP-3 concentrations and significantly higher IGFBP-1 and IGFBP-2 concentrations than women aged 20-24 years. Body mass index (BMI) was not strongly associated with IGF-I, although women with a BMI of 26-27.9 kg/m(2) had a higher IGF-I concentration compared with both lean (BMI