Caffeine decreases intermittent hypoxia in preterm infants nearing term-equivalent age
Caffeine decreases intermittent hypoxia in preterm infants nearing term-equivalent age
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DOI：
10.1038/jp.2017.82
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发表时间：
2017-10-01
影响因子：
2.9
通讯作者：
Hunt, C. E.
中科院分区：
文献类型：
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作者：
Dobson, N. R.;Rhein, L. M.;Hunt, C. E.
目的：为了确定是否间歇性缺氧（IH）持续36周后月经年龄（PMA）可以减弱使用咖啡因剂量足以维持咖啡因浓度420 μ g ml（-1）。研究设计：27名出生< 32周的婴儿开始服用柠檬酸咖啡因10 mg kg（-1）d（-1），当临床咖啡因停止。在36周PMA时，剂量增加到14或20 mg/kg/天，每天分两次（BID），以补偿咖啡因代谢的逐渐增加。每周测量咖啡因浓度。将连续脉搏血氧仪得出的IH程度与53名对照婴儿的数据进行比较。入选婴儿的胎龄为27.9 ± 2周。研究中咖啡因剂量的中位咖啡因水平为420 μ g/ml。IH显着衰减，通过38周PMA与control group.CONCLUSION：咖啡因剂量为14至20毫克公斤（-1）天（-1）足以维持咖啡因浓度420微克毫升（-1），并减少IH早产儿在36至38周PMA。
OBJECTIVE: To determine whether intermittent hypoxia (IH) persisting after 36 weeks postmenstrual age (PMA) can be attenuated using caffeine doses sufficient to maintain caffeine concentrations 420 mu g ml(-1).STUDY DESIGN: Twenty-seven infants born < 32 weeks were started on caffeine citrate at 10 mg kg(-1) day(-1) when clinical caffeine was discontinued. At 36 weeks PMA, the dose was increased to 14 or 20 mg kg(-1) day(-1) divided twice a day (BID) to compensate for progressively increasing caffeine metabolism. Caffeine concentrations were measured weekly. The extent of IH derived from continuous pulse oximetry was compared to data from 53 control infants.RESULT: The mean (s.d.) gestational age of enrolled infants was 27.9 +/- 2 weeks. Median caffeine levels were 420 mu g ml(-1) on study caffeine doses. IH was significantly attenuated through 38 weeks PMA compared with the control group.CONCLUSION: Caffeine doses of 14 to 20 mg kg(-1) day(-1) were sufficient to maintain caffeine concentrations 420 mu g ml(-1) and reduce IH in preterm infants at 36 to 38 weeks PMA.