Isolation of natural plaque-inhibiting substances from 'Nigerian chewing sticks'.
Isolation of natural plaque-inhibiting substances from 'Nigerian chewing sticks'.
复制标题
从“尼日利亚咀嚼棒”中分离出天然牙菌斑抑制物质。
DOI：
10.1159/000260768
复制
发表时间：
1984
期刊：
影响因子：
4.2
通讯作者：
Sote,EO
中科院分区：
文献类型：
--
作者：
Wolinsky,LE;Sote,EO
尼日利亚产的非洲植物Serindeia warnecki、Prosopsis africana、Pseudocedrela kotschyi和Anoigeissus schrimperi的咀嚼棒1%（w/v）的水提物能有效抑制S. mutans 6715 wt 13转化为玻璃或唾液涂覆的羟基磷灰石珠。结果表明，这些提取物中的活性化合物干扰细菌的结合，导致粘附性降低。虽然没有注意到对总的胞外葡聚糖合成的大的影响，但在水不溶性多糖合成中有15%的减少。S有效成分的化学分析和光谱分析。Warnecki表明这种材料具有高分子量多酚单宁的特性。1%单宁酸水溶液也显示出与S.瓦内基总之，结果表明，咀嚼棒成分似乎发挥了重要作用，限制菌斑积累和龋齿的发病率。
Aqueous extracts, 1% (w/v), of Nigerian chewing sticks derived from the African plantsSerindeia warnecki,Prosopsis africana,Pseudocedrela kotschyi, andAnoigeissus schrimperiwere found to effectively inhibit the attachment ofS. mutans6715wt13 to glass or saliva-coated hydroxy-apatite beads. It was shown that the active compounds in these extracts interfere with binding of the bacteria, resulting in reduced adherence. Although no large effect upon the total extracellular glucan synthesis was noted, there was a 15% reduction in the water-insoluble polysaccharide synthesis. Chemical and spectral analysis of the active constituent fromS. warneckishowed this material to have the characteristics of a high molecular weight polyphenolic tannin. 1% aqueous solution of tannic acid was also shown to promote similar in vitro adherence inhibition as the tannin-like substance fromS. warnecki. In conclusion, the results imply that chewing stick constituents appear to play an important role in restricting plaque accumulation and caries incidence.