Effects of Glutamine on Gastrointestinal Motor Activity in Patients following Gastric Surgery
Effects of Glutamine on Gastrointestinal Motor Activity in Patients following Gastric Surgery
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DOI：
10.1007/s00268-011-0962-5
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发表时间：
2011-04-01
影响因子：
2.6
通讯作者：
Kuwano, Hiroyuki
中科院分区：
文献类型：
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作者：
Mochiki, Erito;Ohno, Tetsuro;Kuwano, Hiroyuki
背景术后肠梗阻(POI)是胃肠道手术最常见的并发症之一。为探讨谷氨酰胺对人胃术后POI的影响，将31例胃癌远端胃大部切除术后患者随机分为谷氨酰胺组(3g/d)和对照组。术后12天测压，分别于术前、术后12天测定血浆谷氨酰胺浓度。结果谷氨酰胺组十二指肠消化间期运动活动明显高于对照组。谷氨酰胺组的III相运动活动(消化间期移行性运动收缩)的发生率明显高于对照组(60%比19%)。谷氨酰胺组血浆谷氨酰胺水平下降幅度明显小于对照组。结论谷氨酰胺可作为胃切除术后的动力恢复剂。
Background Postoperative ileus (POI) is one of the most common complications of gastrointestinal surgery. The present study was performed to evaluate the effects of glutamine administration on POI after gastric surgery in humans.Subjects and methods The subjects were 31 patients who underwent partial distal gastrectomy for gastric cancer and who were randomly assigned to one of two groups based on postoperative treatment: the glutamine group (3 g/day) and the control group. Manometric recording was done 12 days after surgery, and plasma glutamine concentrations were measured preoperatively and on postoperative day 12.Results Motor activities of the duodenum in the glutamine group were significantly greater than those of the control group in the interdigestive state. The incidence of phase III motor activity (interdigestive migrating motor contractions) in the glutamine group was significantly higher than that in the control group (60 versus 19%). The glutamine group showed a significantly smaller decrease of plasma glutamine levels compared with the control group.Conclusions Glutamine could act as a motility-recovery agent after gastrectomy in humans.