Differentiation of glioblastoma multiforme and single brain metastasis by peak height and percentage of signal intensity recovery derived from dynamic susceptibility-weighted contrast-enhanced perfusion MR imaging
Differentiation of glioblastoma multiforme and single brain metastasis by peak height and percentage of signal intensity recovery derived from dynamic susceptibility-weighted contrast-enhanced perfusion MR imaging
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DOI：
10.3174/ajnr.a0484
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发表时间：
2007-06-01
影响因子：
3.5
通讯作者：
Dillon, W. P.
中科院分区：
文献类型：
--
作者：
Cha, S.;Lupo, J. M.;Dillon, W. P.
背景和目的：多形性胶质母细胞瘤（GBM）和单发脑转移瘤（MET）是2种最常见的恶性脑肿瘤，在解剖成像上表现相似，但需要截然不同的治疗策略。我们的研究的目的是确定是否峰高和信号强度恢复的百分比来自动态磁共振增强QSQ灌注成像可以区分GBM和MET.MATERIALS和MET. METHODS：43例GBM（n = 27）或MET的组织病理学诊断的患者在= 16）进行DSC灌注MR成像，除了解剖MR成像术前。在无增强的T2期周围病变（PTL）和造影剂增强病变（CEL）周围绘制感兴趣区域。将钆对比剂第一次通过时获得的T2* 信号强度-时间曲线转换为弛豫速率的变化，得到T2* 弛豫率（Delta R2*）曲线。在PTL和CEL区域的肿瘤的每个体素的最大信号强度下降的峰高和信号强度恢复在第一遍结束时的百分比进行测量。结果：PTL的平均峰高显着高于（P = 0.04）在GBM比MET。在PTL（78.4%对82.8%; P = 0.02）和CEL（62.5%对80.9%，P = 0.05）中，信号强度恢复的平均百分比显著降低。
BACKGROUND AND PURPOSE: Glioblastoma multiforme (GBM) and single brain metastasis (MET) are the 2 most common malignant brain tumors that can appear similar on anatomic imaging but require vastly different treatment strategy. The purpose of our study was to determine whether the peak height and the percentage of signal intensity recovery derived from dynamic susceptibility-weighted contrast-enhanced QSQ perfusion MR imaging could differentiate GBM and MET.MATERIALS AND METHODS: Forty-three patients with histopathologic diagnosis of GBM (n = 27) or MET In = 16) underwent DSC perfusion MR imaging in addition to anatomic MR imaging before surgery. Regions of interest were drawn around the nonenhancing periturnoral T2 lesion (PTL) and the contrast-enhancing lesion (CEL). T2* signal intensity-time curves acquired during the first pass of gadolinium contrast material were converted to the changes in relaxation rate to yield T2* relaxivity (Delta R2*) curve. The peak height of maximal signal intensity drop and the percentage of signal intensity recovery at the end of first pass were measured for each voxel in the PTL and CEL regions of the tumor.RESULTS: The average peak height for the PTL was significantly higher (P =.04) in GBM than in MET. The average percentage of signal intensity recovery was significantly reduced in PTL (78.4% versus 82.8%; P =.02) and in CEL (62.5% versus 80.9%, P