Activation of cardiac gene expression by myocardin, a transcriptional cofactor for serum response factor
Activation of cardiac gene expression by myocardin, a transcriptional cofactor for serum response factor
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DOI：
10.1016/s0092-8674(01)00404-4
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发表时间：
2001-06-29
期刊：
影响因子：
64.5
通讯作者：
Olson, EN
中科院分区：
文献类型：
--
作者：
Wang, DZ;Chang, PS;Olson, EN
Serum response factor (SRF) regulates transcription of numerous muscle and growth factor-inducible genes. Because SRF is not muscle specific, It has been postulated to activate muscle genes by recruiting myogenic accessory factors. Using a bioinformatics-based screen for unknown cardiac-specific genes, we identified a novel and highly potent transcription factor, named myocardin, that is expressed in cardiac and smooth muscle cells. Myocardin belongs to the SAP domain family of nuclear proteins and activates cardiac muscle promoters by associating with SRF. Expression of a dominant negative mutant of myocardin in Xenopus embryos interferes with myocardial cell differentiation. Myocardin is the founding member of a class of muscle transcription factors and provides a mechanism whereby SRF can convey myogenic activity to cardiac muscle genes.
