The metabolic syndrome, circulating oxidized LDL, and risk of myocardial infarction in well-functioning elderly people in the health, aging, and body composition cohort
The metabolic syndrome, circulating oxidized LDL, and risk of myocardial infarction in well-functioning elderly people in the health, aging, and body composition cohort
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DOI：
10.2337/diabetes.53.4.1068
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发表时间：
2004-04-01
期刊：
影响因子：
7.7
通讯作者：
Harris, TB
中科院分区：
文献类型：
--
作者：
Holvoet, P;Kritchevsky, SB;Harris, TB
本研究的目的是建立代谢综合征和氧化低密度脂蛋白（oxLDL）之间的联系，并确定冠心病（CHD）的风险与代谢综合征和oxLDL水平的关系。在健康、衰老和身体成分研究中，对3,033名老年参与者的血浆中的OxLDL进行了测量。根据国家胆固醇教育计划专家小组关于成人高血胆固醇检测、评估和治疗的第三次报告中建立的标准定义代谢综合征。我们观察到，代谢综合征与较高水平的oxLDL相关，这是由于oxLDL含量较高，而不是与较高水平的LDL胆固醇相关。在调整了年龄、性别、种族、吸烟状况和LDL胆固醇后，与未患代谢综合征的人相比，患有代谢综合征的人患高oxLDL（>1.90 mg/dl）的几率是其两倍。在研究开始时患有代谢综合征的参与者中，在调整年龄、性别、种族和吸烟状况后，未来CHD事件的发生率高1.6倍。OxLDL不是CHD总风险的独立预测因子。然而，那些高oxLDL显示出更大的倾向于心肌梗死（相对风险2.25，95%置信区间1.22-4.15）。我们的结论是，代谢综合征，冠心病的危险因素，是与循环氧化低密度脂蛋白水平较高，与动脉粥样硬化血栓性冠状动脉疾病的更大的处置。
The object of this study was to establish the association between the metabolic syndrome and oxidized LDL (oxLDL) and to determine the risk for coronary heart disease (CHD) in relation to the metabolic syndrome and levels of oxLDL. OxLDL was measured in plasma from 3,033 elderly participants in the Health, Aging, and Body Composition study. The metabolic syndrome was defined according to criteria established in the Third Report of the National Cholesterol Education Program Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. We observed that the metabolic syndrome was associated with higher levels of oxLDL due to a higher fraction of oxLDL, not to higher levels of LDL cholesterol. Individuals with the metabolic syndrome had twice the odds of having high oxLDL (>1.90 mg/dl) compared with those not having the metabolic syndrome, after adjusting for age, sex, ethnicity, smoking status, and LDL cholesterol. Among those participants who had the metabolic syndrome at study entry, incidence rates of future CHD events were 1.6-fold higher, after adjusting for age, sex, ethnicity, and smoking status. OxLDL was not an independent predictor of total CHD risk. However, those with high oxLDL showed a greater disposition to myocardial infarction (relative risk 2.25, 95% confidence interval 1.22-4.15). We concluded that the metabolic syndrome, a risk factor for CHD, is associated with higher levels of circulating oxLDL that are associated with a greater disposition to atherothrombotic coronary disease.