Pipe Phantoms With Applications in Molecular Imaging and System Characterization.
Pipe Phantoms With Applications in Molecular Imaging and System Characterization.
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DOI：
10.1109/tuffc.2016.2626465
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发表时间：
2017-01
期刊：
影响因子：
--
通讯作者：
Hossack JA
中科院分区：
文献类型：
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作者：
Wang S;Herbst EB;Pye SD;Moran CM;Hossack JA
模仿人体组织和血流的管道（血管）体模广泛应用于医学超声心血管相关研究。管道模型研究需要开发与软组织、血管壁和血液的声学特性相匹配的材料和液体。近年来，已经开发出管道模型来模仿模拟血管的分子特性。本文介绍了管道模型的设计、构造和功能化，并对其在分子成像和超声成像系统表征中的应用进行了验证。引入了三种主要类型的管道模型：基于明胶的管道模型、基于聚二甲基硅氧烷（PDMS）的管道模型和“爱丁堡管道模型”（EPP）。这些模型可用于验证和评估基于微泡的造影剂的动力学，并且在小直径管模型 (EPP) 的情况下，可用于评估成像系统的空间分辨率/对比度性能。描述了处理每个模型所需的材料和程序。
Pipe (vessel) phantoms mimicking human tissue and blood flow are widely used for cardiovascular related research in medical ultrasound. Pipe phantom studies require the development of materials and liquids that match the acoustic properties of soft tissue, blood vessel wall, and blood. Over recent years, pipe phantoms have been developed to mimic the molecular properties of the simulated blood vessels. In this paper, the design, construction, and functionalization of pipe phantoms are introduced and validated for applications in molecular imaging and ultrasound imaging system characterization. There are three major types of pipe phantoms introduced: a gelatin-based pipe phantom, a polydimethylsiloxane (PDMS)-based pipe phantom, and the “Edinburgh Pipe Phantom” (EPP). These phantoms may be used in the validation and assessment of the dynamics of microbubble-based contrast agents and, in the case of a small diameter tube phantom (EPP), for assessing imaging system spatial resolution/contrast performance. The materials and procedures required to address each of the phantoms are described.