Effect of regular maternal exercise on lipid peroxidation levels and antioxidant enzymatic activities before and after delivery.
Effect of regular maternal exercise on lipid peroxidation levels and antioxidant enzymatic activities before and after delivery.
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DOI：
10.1272/jnms.69.542
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发表时间：
2002-12-01
影响因子：
1
通讯作者：
Araki, Tsutomu
中科院分区：
文献类型：
--
作者：
Kobe, Hitoshi;Nakai, Akihito;Araki, Tsutomu
本研究旨在探讨有氧运动对产妇分娩前后脂质过氧化水平和抗氧化酶活性的影响。从18名在整个怀孕期间定期锻炼的未经产健康孕妇和22名匹配的对照组中收集了分娩前和产后1小时和24小时的血液样本。测定血浆丙二醛（MDA）浓度作为脂质过氧化反应的指标。红细胞酶，超氧化物歧化酶（SOD），谷胱甘肽过氧化物酶（GSHPx）和过氧化氢酶（CAT），测定细胞内的抗氧化标记物。对照组MDA从产前至产后1h轻度升高，产后24h显著升高，SOD、CAT活性显著升高。而运动组的MDA在产后1和24小时无明显变化。运动组产后1h SOD、CAT水平明显升高，随后下降至产前水平。目前的研究结果表明，不受控制的脂质过氧化反应发生在劳动过程中，并建议继续定期产妇运动可能会减少劳动引起的脂质过氧化反应，提高对自由基的产生的防御能力。
This study was designed to investigate the influence of maternal aerobic exercise on lipid peroxidation levels and antioxidant enzymatic activities before and after delivery. Predelivery and 1- and 24-hour post partum blood samples were collected from 18 nulliparous healthy pregnant women who exercised regularly throughout the whole period of pregnancy and from 22 matched controls. The plasma concentration of malondialdehyde (MDA) was measured as an indicator of lipid peroxidation. Erythrocyte enzymes, superoxide dismutase (SOD), glutathione peroxidase (GSHPx) and catalase (CAT), were measured as intracellular antioxidant markers. In the control group, MDA increased slightly from predelivery to 1 hour post partum and then increased significantly at 24 hours post partum, with significant increase in SOD and CAT activities. On the other hand, MDA of the exercise group remained unaltered at 1 and 24 hours after delivery. At 1 hour post partum, the SOD and CAT levels of the exercise group increased markedly and then decreased to predelivery levels. The present results indicate that uncontrolled lipid peroxidation occurs during labor and suggest that continuing regular maternal exercise may reduce labor-induced lipid peroxidation by improving the defense capabilities against free radical generation.