Silencing gut CCK cells alters gut reaction to sugar.
Silencing gut CCK cells alters gut reaction to sugar.
复制标题
沉默肠道 CCK 细胞会改变肠道对糖的反应。
DOI：
10.1038/s41593-021-00998-z
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发表时间：
2022
影响因子：
25
通讯作者：
Lam,TonyKT
中科院分区：
文献类型：
--
作者：
Yue,JessicaTY;Duca,FrankA;Lam,TonyKT
十二指肠区分糖和甜味剂，但参与这一过程的细胞仍然难以捉摸。布坎南和他的同事设计了一种柔性光纤，用于对小鼠肠道细胞进行光遗传操作。抑制十二指肠CCK细胞减少了对糖的偏好，而不是甜味剂的摄入。肠道光遗传学可能会阐明肠道-脑轴如何调节摄食和葡萄糖动态平衡。
The duodenum distinguishes between sugar and sweeteners, but the cells involved in this process remain elusive. Buchanan and colleagues engineered a flexible optic fiber for optogenetic manipulation of gut cells in mice. Silencing duodenal CCK cells reduced the preference for sugar over sweetener intake. Gut optogenetics may elucidate how the gut–brain axis regulates feeding and glucose homeostasis.