Spatial Partitioning of miRNAs Is Related to Sequence Similarity in Overall Transcriptome.
Spatial Partitioning of miRNAs Is Related to Sequence Similarity in Overall Transcriptome.
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DOI：
10.3390/ijms17060830
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发表时间：
2016-06-08
影响因子：
5.6
通讯作者：
Wang XQ
中科院分区：
文献类型：
--
作者：
Seffens W;Abebe F;Evans C;Wang XQ
RNA已被证明在核组分、细胞质组分和外体组分之间表现出不同的富集性。当前的一个基本问题是，为什么非编码RNA划分为不同的空间间隔。我们报告了使用miRNA数据源进行空间-机械建模的细胞室模型的分析，以解决由miRNAs进行的多标量细胞通信的广泛领域。我们发现miRNAs的空间分割与整个转录组的序列相似性有关。这在生物信息学中对基因调控具有广泛的意义，并为更深入地理解核苷酸序列结构和基因表达变化导致的人类病理的RNA语言意义提供了更深层次的理解。
RNAs have been shown to exhibit differential enrichment between nuclear, cytoplasmic, and exosome fractions. A current fundamental question asks why non-coding RNA partition into different spatial compartments. We report on the analysis of cellular compartment models with miRNA data sources for spatial-mechanistic modeling to address the broad area of multi-scalar cellular communication by miRNAs. We show that spatial partitioning of miRNAs is related to sequence similarity to the overall transcriptome. This has broad implications in biological informatics for gene regulation and provides a deeper understanding of nucleotide sequence structure and RNA language meaning for human pathologies resulting from changes in gene expression.