A role for carbohydrates in immune evasion in AIDS
A role for carbohydrates in immune evasion in AIDS
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DOI：
10.1038/nm0698-679
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发表时间：
1998-06-01
期刊：
影响因子：
82.9
通讯作者：
Desrosiers, RC
中科院分区：
文献类型：
--
作者：
Reitter, JN;Means, RE;Desrosiers, RC
恒河猴感染了猴免疫缺陷病毒的突变形式，该病毒的外膜糖蛋白缺乏第4、5和6位N-连接糖基化的双重组合。与感染亲本病毒的猕猴血清相比，突变病毒感染的猴血清与该区域的特异性多肽的抗体结合率显著增加，中和活性显著增强。这些结果表明N-连接的糖基化在限制对SIV的中和抗体反应和保护病毒免受免疫识别方面的作用。
Rhesus monkeys were infected with mutant forms of simian immunodeficiency virus lacking dual combinations of the 4th, 5th and 6th sites for N-linked glycosylation in the external envelope glycoprotein of the virus. When compared with sera from monkeys infected with the parental virus, sera from monkeys infected with the mutant viruses exhibited markedly increased antibody binding to specific peptides from this region and markedly increased neutralizing activity. These results demonstrate a role for N-linked glycosylation in limiting the neutralizing antibody response to SIV and in shielding the virus from immune recognition.