Clinical validation of high-resolution image reconstruction algorithms in brain 18F-FDG-PET: effect of incorporating Gaussian filter, point spread function, and time-of-flight
Clinical validation of high-resolution image reconstruction algorithms in brain 18F-FDG-PET: effect of incorporating Gaussian filter, point spread function, and time-of-flight
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DOI：
10.1097/mnm.0000000000000187
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发表时间：
2014-12-01
影响因子：
1.5
通讯作者：
Matsutomo, Norikazu
中科院分区：
文献类型：
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作者：
Nagaki, Akio;Onoguchi, Masahisa;Matsutomo, Norikazu
目的由于计数统计、低空间分辨率和平滑滤波等原因，准确估计脑内放射性药物摄取是困难的。本研究的目的是评估PET扫描仪的计数率性能和图像质量与不同组合的高分辨率图像重建算法在脑F-18-2-氟脱氧-d-葡萄糖（F-18-FDG）-PET。材料和方法使用23例患者研究，我们分析了真实和随机，随机分数，以及脑床和肝床位置中每轴向长度的噪声等效计数（NEC患者）。重建算法结合了基线有序子集期望最大化、高斯滤波（GF）、点扩散函数（PSF）和飞行时间（TOF）。结果与肝脏比较，脑皮质的真实符合率高1.86倍，随机符合率低0.61倍。在脑中，随机分数低于肝，NEC患者高于肝。虽然GF提高了SNR，但空间分辨率和对比度分别降低了12%和11%（P
ObjectivesAccurate estimation of radiopharmaceutical uptake in the brain is difficult because of count statistics, low spatial resolution, and smoothing filter. The aim of this study was to assess the counting rate performance of PET scanners and the image quality with different combinations of high-resolution image reconstruction algorithms in brain F-18-2-fluorodeoxy-d-glucose (F-18-FDG)-PET.Materials and methodsUsing 23 patient studies, we analyzed the coincidence rates of true and random, random fraction, and the noise equivalent counts per axial length (NECpatient) in brain and liver bed positions. The reconstruction algorithms were combined with baseline ordered subsets expectation maximization, Gaussian filter (GF), point spread function (PSF), and time-of-flight (TOF). The image quality of the brain cortex was quantitatively evaluated with respect to spatial resolution, contrast, and signal-to-noise ratio (SNR).ResultsThe true coincidence rate in the brain was higher by 1.86 times and the random coincidence rate was lower by 0.61 times compared with that in the liver. In the brain, random fraction was lower and NECpatient was higher than that of the liver. Although GF improved the SNR, spatial resolution and contrast were reduced by 12 and 11%, respectively (P