Somatosensory evoked potentials and magnetic fields elicited by tactile stimulation of the hand during active and quiet sleep in newborns
Somatosensory evoked potentials and magnetic fields elicited by tactile stimulation of the hand during active and quiet sleep in newborns
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DOI：
10.1016/s1388-2457(03)00349-3
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发表时间：
2004-02
影响因子：
4.7
通讯作者：
E. Pihko;L. Lauronen;H. Wikström;S. Taulu;J. Nurminen;S. Kivitie‐Kallio;Y. Okada
中科院分区：
文献类型：
--
作者：
E. Pihko;L. Lauronen;H. Wikström;S. Taulu;J. Nurminen;S. Kivitie‐Kallio;Y. Okada
我们的目的是表征睡眠阶段对触觉体感诱发反应的影响在足月新生儿。MethodsSomatosensory诱发电位（SEP）和磁场（SEFs）触觉刺激的食指和/或鱼际隆起的14名健康新生儿进行了测量。刺激是一个温和的水龙头产生的移动膜驱动的空气压力pulse.ResultsSEPs和SEFs触觉刺激的皮肤是类似的波形和潜伏期，以SEPs已知的新生儿指尖的电刺激产生。两个最明显的积极偏转的SEPs，P1和P2，在300毫秒的刺激，和他们的磁对应物明显较小的活跃相比，安静的sleep.ConclusionsOur研究表明，它是第一次有可能记录SEFs在新生儿中，和明确的晚期皮层体感反应产生的触觉刺激。此外，睡眠阶段对这些反应的影响表明，在传入的信息的处理，至少在躯体感觉的方式，在活跃和安静的sleep.SignificanceTactile刺激可能是有用的，作为一个完全非侵入性的技术，用于研究新生儿的躯体感觉系统的生理。从方法论上讲，由于睡眠阶段的影响是深刻的，必须仔细监测新生儿事件相关反应的研究中的睡眠阶段，否则这种影响可能会混淆正在研究的现象。
ObjectiveOur objective was to characterize the effects of sleep stages on tactile somatosensory evoked responses in full-term newborns.MethodsSomatosensory evoked potentials (SEPs) and magnetic fields (SEFs) to tactile stimulation of the tip of the index finger and/or thenar eminence were measured from 14 healthy newborns. The stimulus was a gentle tap produced by a moving membrane driven by an air-pressure pulse.ResultsSEPs and SEFs to tactile stimulation of the skin were similar in waveform and latency to SEPs known to be produced by electrical stimulation of the fingertip of neonates. The two most distinguishable positive deflections of SEPs, P1 and P2, within 300 ms of the stimulation, and their magnetic counterparts were clearly smaller in active compared to quiet sleep.ConclusionsOur study demonstrates for the first time that it is possible to record SEFs in neonates, and that clear late cortical somatosensory responses are produced by tactile stimulation. In addition, the effect of sleep stage on these responses indicates differences in the processing of the incoming information, at least in the somatosensory modality, in active and quiet sleep.SignificanceTactile stimulation may be useful as a completely non-invasive technique for studying the physiology of the somatosensory system in neonates. Methodologically, since the effect of sleep stage is profound, one must carefully monitor the sleep stages in studies of event-related responses in newborns, or else this effect may confound the phenomena being studied.