Noninvasive measurement of sensory action currents in the cervical cord by magnetospinography
Noninvasive measurement of sensory action currents in the cervical cord by magnetospinography
复制标题
通过磁电描记法无创测量颈髓中的感觉动作电流
DOI：
10.1016/j.clinph.2020.11.029
复制
发表时间：
2021
影响因子：
4.7
通讯作者：
Yokota Takanori
中科院分区：
文献类型：
--
作者：
Akaza Miho;Kawabata Shigenori;Ozaki Isamu;Miyano Yuki;Watanabe Taishi;Adachi Yoshiaki;Sekihara Kensuke;Sumi Yuki;Yokota Takanori
目的获得磁记录的电活动在颈髓和可视化的感觉动作电流的背柱，椎间孔，和背角。MethodsNeuromagnetic fields测量在颈部表面正中神经刺激后，在手腕使用磁脊髓造影系统与高灵敏度超导量子干涉器件传感器。还记录了体感诱发电位（SEP）。诱发电流重建递归零转向波束形成器和叠加在颈部X射线images.ResultsEstimated电流垂直于颈髓上升顺序。16例受试者SEP的C5峰潜伏期和N11峰潜伏期均呈显著正相关（r = 0.94，p < 0.0001）。在10名参与者中估计椎间孔中的尾随轴突电流。在C5椎管内获得估计的背腹侧电流。在13例受试者中，电流密度峰潜伏期与SEP的颈部N13-P13峰潜伏期显著相关结论脊髓磁图在正中神经刺激后具有良好的空间和时间分辨率，可以确定脊神经根入路平面，计算背柱传导速度，意义该方法可用于躯体感觉通路的功能电生理诊断。
ObjectiveTo obtain magnetic recordings of electrical activities in the cervical cord and visualize sensory action currents of the dorsal column, intervertebral foramen, and dorsal horn.MethodsNeuromagnetic fields were measured at the neck surface upon median nerve stimulation at the wrist using a magnetospinography system with high-sensitivity superconducting quantum interference device sensors. Somatosensory evoked potentials (SEPs) were also recorded. Evoked electrical currents were reconstructed by recursive null-steering beamformer and superimposed on cervical X-ray images.ResultsEstimated electrical currents perpendicular to the cervical cord ascended sequentially. Their peak latency at C5 and N11 peak latency of SEP were well-correlated in all 16 participants (r = 0.94, p < 0.0001). Trailing axonal currents in the intervertebral foramens were estimated in 10 participants. Estimated dorsal–ventral electrical currents were obtained within the spinal canal at C5. Current density peak latency significantly correlated with cervical N13–P13 peak latency of SEPs in 13 participants (r = 0.97, p < 0.0001).ConclusionsMagnetospinography shows excellent spatial and temporal resolution after median nerve stimulation and can identify the spinal root entry level, calculate the dorsal column conduction velocity, and analyze segmental dorsal horn activity.SignificanceThis approach is useful for functional electrophysiological diagnosis of somatosensory pathways.