Impairment of the glymphatic system after diabetes
Impairment of the glymphatic system after diabetes
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DOI：
10.1177/0271678x16654702
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发表时间：
2017-04-01
影响因子：
6.3
通讯作者：
Zhang, Zhenggang
中科院分区：
文献类型：
--
作者：
Jiang, Quan;Zhang, Li;Zhang, Zhenggang
胶质淋巴系统最近被证明可以清除脑细胞外溶质，胶质淋巴清除系统的异常可能有助于神经系统疾病的发生和进展。尽管糖尿病被认为是血管疾病的危险因素，但人们对糖尿病如何影响胶质淋巴系统知之甚少。本研究首次研究了糖尿病对胶质淋巴系统的影响以及胶质淋巴清除率改变与2型糖尿病大鼠认知障碍之间的联系。MRI分析显示，脑脊液造影剂Gd-DTPA从间质间隙的清除减慢了3倍的2型糖尿病大鼠海马相比，非DM大鼠，并证实了荧光成像分析。2型糖尿病大鼠海马Gd-DTPA造影剂和荧光示踪剂的保留与行为学检测的认知功能障碍呈高度负相关。2型糖尿病抑制海马和下丘脑中间质液的清除，表明胶质淋巴系统的损伤有助于2型糖尿病诱导的认知缺陷。全脑MRI为定量评价2型糖尿病和其他神经系统疾病的脑脊液和间质液交换提供了一种灵敏、无创的工具，具有潜在的临床应用价值。
The glymphatic system has recently been shown to clear brain extracellular solutes and abnormalities in glymphatic clearance system may contribute to both initiation and progression of neurological diseases. Despite that diabetes is known as a risk factor for vascular diseases, little is known how diabetes affects the glymphatic system. The current study is the first investigation of the effect of diabetes on the glymphatic system and the link between alteration of glymphatic clearance and cognitive impairment in Type-2 diabetes mellitus rats. MRI analysis revealed that clearance of cerebrospinal fluid contrast agent Gd-DTPA from the interstitial space was slowed by a factor of three in the hippocampus of Type-2 diabetes mellitus rats compared to the non-DM rats and confirmed by florescence imaging analysis. Cognitive deficits detected by behavioral tests were highly and inversely correlated to the retention of Gd-DTPA contrast and fluorescent tracer in the hippocampus of Type-2 diabetes mellitus rats. Type-2 diabetes mellitus suppresses clearance of interstitial fluid in the hippocampus and hypothalamus, suggesting that an impairment of the glymphatic system contributes to Type-2 diabetes mellitus-induced cognitive deficits. Whole brain MRI provides a sensitive, non-invasive tool to quantitatively evaluate cerebrospinal fluid and interstitial fluid exchange in Type-2 diabetes mellitus and possibly in other neurological disorders, with potential clinical application.