PPAR-γ:: Adipogenic regulator and thiazolidinedione receptor
PPAR-γ:: Adipogenic regulator and thiazolidinedione receptor
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DOI：
10.2337/diabetes.47.4.507
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发表时间：
1998-04-01
期刊：
影响因子：
7.7
通讯作者：
Spiegelman, BM
中科院分区：
文献类型：
--
作者：
Spiegelman, BM
在过去的几年里，我们对脂肪细胞分化的转录基础的理解有了爆炸性的增长。特别是，一个关键的作用已经说明了PPAR-gamma，核激素受体超家族的成员。PPAR-gamma最近也被鉴定为噻唑烷二酮类胰岛素增敏药物的主要功能受体。这篇评论探讨了证据表明，有牵连的脂肪形成和全身胰岛素作用的过程中，这种转录因子。此外，几个模型进行了讨论，可以解释如何一个单一的蛋白质可以参与这些相关的，但不同的生理作用。我还指出了几个重要领域，我们的知识是不完整的，需要更多的研究。最后，我将讨论如何在我们的核受体功能的理解，特别是在配体依赖性的方式对接的辅因子的进步，应导致改善药物，利用PPAR-gamma系统治疗胰岛素抵抗。
The past several years have seen an explosive increase in our understanding of the transcriptional basis of adipose cell differentiation. In particular, a key role has been illustrated for PPAR-gamma, a member of the nuclear hormone receptor superfamily. PPAR-gamma has also been recently identified as the major functional receptor for the thiazolidinedione class of insulin-sensitizing drugs. This review examines the evidence that has implicated this transcription factor in the processes of adipogenesis and systemic insulin action. In addition, several models are discussed that may explain how a single protein can be involved in these related but distinct physiological actions. I also point out several important areas where our knowledge is incomplete and more research is needed. Finally, I discuss how advances in our understanding of nuclear receptor function, particularly the docking of cofactors in a ligand-dependent fashion, should lead to improved drugs that utilize the PPAR-gamma system for the treatment of insulin resistance.