MERKEL-LIKE BASAL CELLS IN NECTURUS TASTE-BUDS CONTAIN SEROTONIN
MERKEL-LIKE BASAL CELLS IN NECTURUS TASTE-BUDS CONTAIN SEROTONIN
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DOI：
10.1002/cne.903350411
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发表时间：
1993-09-22
影响因子：
2.5
通讯作者：
ROPER, SD
中科院分区：
文献类型：
--
作者：
DELAY, RJ;TAYLOR, R;ROPER, SD
在脊椎动物味蕾中已经鉴定出几种类型的细胞，包括暗细胞、亮细胞、中间细胞、III型细胞和基底细胞。这些细胞类型的生理作用还不清楚，特别是基底细胞。在本文中，我们发现有两种类型的基底细胞的Necturusmaculosus的味蕾。一种类型的基底细胞是未分化的细胞，可能是干细胞。通过结合光镜免疫细胞化学和电子显微镜，我们发现，其他类型的基底细胞是阳性的类胡萝卜素的免疫反应性，这些细胞的超微结构特征相似，发现在皮肤默克尔细胞。基于这些发现，以及Merkel样味细胞已被证明与相邻的味细胞和神经支配的神经纤维进行突触接触的事实，我们得出结论，这些Merkel样基底味细胞是神经元能中间神经元。 (C)1993 Wiley-Liss，Inc.
Several types of cells have been identified in vertebrate taste buds, including dark cells, light cells, intermediate cells, type III cells, and basal cells. The physiological roles of these cell types are not well understood, especially those of basal cells. In this paper we show that there are two types of basal cells in taste buds from Necturus maculosus. One type of basal cell is an undifferentiated cell, presumably a stem cell. By combining light microscopic immunocytochemistry with electron microscopy, we show that the other type of basal cell is positive for serotonin-like immunoreactivity and that these cells have ultrastructural features similar to those found in cutaneous Merkel cells. Based on these findings, and the fact that the Merkel-like taste cells have been shown to make synaptic contacts with adjacent taste cells and with innervating nerve fibers, we conclude that these Merkel-like basal taste cells are serotonergic interneurons. (C) 1993 Wiley-Liss, Inc.