Predicting the risk of diabetic retinopathy in type 2 diabetic patients
Predicting the risk of diabetic retinopathy in type 2 diabetic patients
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DOI：
10.1016/j.jdiacomp.2010.12.002
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发表时间：
2011-09-01
影响因子：
3
通讯作者：
Costagliola, Ciro
中科院分区：
文献类型：
--
作者：
Semeraro, Francesco;Parrinello, Giovanni;Costagliola, Ciro
目的：糖尿病视网膜病变 (DR) 即使在晚期也常常无症状。及时、重复的 DR 筛查可以避免 DR 的晚期诊断，但糖尿病患者数量较多，无法进行频繁筛查；因此，需要一种方法来识别 DR 风险较高的患者。方法：对 1996 年至 2007 年期间未受视网膜病变影响的 5034 名 2 型糖尿病患者进行前瞻性分析。患者被随机分为两组（比例 2:1）：训练数据组和测试组（分别为 3327 名患者和 1707 名患者）。通过Cox比例风险模型评估与DR发生相关的因素。结果：糖尿病病程、糖化血红蛋白、收缩压、男性。白蛋白尿和除饮食之外的糖尿病治疗均与 DR 的发生显着相关。结论：列线图有助于对 2 型糖尿病患者进行 DR 风险分级，从而需要更频繁的眼科检查，而不会增加时间和成本。 (C) 2011 Elsevier Inc. 保留所有权利。
Aims: Diabetic retinopathy (DR) is often asymptomatic even in its more advanced stages. Timely and repeated screening for DR avoids a late diagnosis of DR, but the high number of diabetic patients precludes a frequent screening; thus, the need for a method to identify patients at higher risk for DR becomes crucial.Methods: A prospective analysis of 5034 type 2 diabetic patients followed from 1996 to 2007 and not affected by retinopathy at the time of the recruitment was performed. Patients were randomly divided (ratio 2:1) into two groups: the train data set and the test set (3327 and 1707 patients, respectively). Factors associated with the occurrence of DR were assessed by the Cox's proportional hazard model.Results: Duration of diabetes, glycosylated hemoglobin, systolic blood Pressure, male gender. albuminuria and diabetes therapy other than diet were all significantly associated with the occurrence of DR.Conclusions: The nomogram could help in ranking the type 2 diabetic patients at higher risk to develop DR and thus with a need for more frequent ophthalmologic checks, without enhancing neither the time nor the costs. (C) 2011 Elsevier Inc. All rights reserved.