Mitochondria-ros crosstalk in the control of cell death and aging.
Mitochondria-ros crosstalk in the control of cell death and aging.
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DOI：
10.1155/2012/329635
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Pinton P
中科院分区：
文献类型：
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作者：
Marchi S;Giorgi C;Suski JM;Agnoletto C;Bononi A;Bonora M;De Marchi E;Missiroli S;Patergnani S;Poletti F;Rimessi A;Duszynski J;Wieckowski MR;Pinton P
活性氧（ROS）是一种高活性分子，主要产生于线粒体内，可以氧化DNA、蛋白质和脂质。在生理水平上，ROS在细胞内信号传导和调节中起“氧化还原信使”的作用，而过量的ROS通过促进内在凋亡途径诱导细胞死亡。最近的工作指出了ROS在自噬激活中的进一步作用及其在衰老调节中的重要性。这篇综述将集中在线粒体作为生产者和ROS的目标，并将总结不同的蛋白质，调节细胞的氧化还原状态。此外，将报告ROS和线粒体参与控制寿命的不同分子途径，指出ROS作为“力量平衡”的作用，指导细胞走向生命或死亡。
Reactive oxygen species (ROS) are highly reactive molecules, mainly generated inside mitochondria that can oxidize DNA, proteins, and lipids. At physiological levels, ROS function as “redox messengers” in intracellular signalling and regulation, whereas excess ROS induce cell death by promoting the intrinsic apoptotic pathway. Recent work has pointed to a further role of ROS in activation of autophagy and their importance in the regulation of aging. This review will focus on mitochondria as producers and targets of ROS and will summarize different proteins that modulate the redox state of the cell. Moreover, the involvement of ROS and mitochondria in different molecular pathways controlling lifespan will be reported, pointing out the role of ROS as a “balance of power,” directing the cell towards life or death.