Nur77 deficiency leads to systemic inflammation in elderly mice.
Nur77 deficiency leads to systemic inflammation in elderly mice.
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Nur77 缺陷导致老年小鼠全身炎症
DOI：
10.1186/s12950-015-0085-0
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Wu H
中科院分区：
文献类型：
--
作者：
Li XM;Lu XX;Xu Q;Wang JR;Zhang S;Guo PD;Li JM;Wu H
NUR77是核受体超家族的孤儿成员，参与了炎症的调节。然而，Nur77的活体功能在很大程度上仍未被探索。在本研究中，我们研究了Nur77在小鼠炎症和免疫中的作用。结果发现，8月龄的Nur77缺陷小鼠(Nur77−/−)发生了全身炎症。与野生型(WT)小鼠(NUR77+/+)相比，NUR77−/−小鼠脾肿大，肝、肺、脾、肾等脏器炎性细胞浸润严重，肺纤维组织增生增多，肾小球增大。此外，Nur77−/−小鼠还能增加促炎细胞因子和免疫球蛋白的产生，并引起巨噬细胞促炎M1样极化，表现为CXCL11和INDO表达增加，MRC1表达降低。结论这些活体观察为Nur77在全身炎症调节中的关键作用提供了证据，并强调了Nur77在体内的致病意义。
BackgroundNur77, an orphan member of the nuclear receptor superfamily, has been implicated in the regulation of inflammation. However, thein vivofunction of Nur77 remains largely unexplored. In the current study, we investigated the role of Nur77 in inflammation and immunity in mice.FindingsWe found that elderly 8-month-old Nur77-deficient mice (Nur77−/−) developed systemic inflammation. Compared to wild-type (WT) mice (Nur77+/+), Nur77−/−mice showed splenomegaly, severe infiltration of inflammatory cells in several organs including liver, lung, spleen and kidney, increased hyperplasia of fibrous tissue in the lung and enlargement of kidney glomeruli. Additionally, Nur77−/−mice had increased production of pro-inflammatory cytokines and immunoglobulin, and elicited pro-inflammatory M1-like polarization in macrophages as revealed by increased expression of CXCL11 and INDO, and decreased expression of MRC1.ConclusionsThesein vivoobservations provide evidence for a pivotal role for Nur77 in the regulation of systemic inflammation and emphasize the pathogenic significance of Nur77in vivo.
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影响因子：
11.2
作者：
Lee SO;Abdelrahim M;Yoon K;Chintharlapalli S;Papineni S;Kim K;Wang H;Safe S
通讯作者：
Safe S
影响因子：
2.8
作者：
Uhrin, P.;Perkmann, T.;Binder, B.;Schabbauer, G.
通讯作者：
Schabbauer, G.
影响因子：
--
作者：
Pei, LM;Castrillo, A;Tontonoz, P
通讯作者：
Tontonoz, P
DOI：
10.1073/pnas.1200090109
发表时间：
2012-03-06
影响因子：
11.1
作者：
Fassett, Marlys S.;Jiang, Wenyu;Benoist, Christophe
通讯作者：
Benoist, Christophe
影响因子：
14.8
作者：
Zhan, Yan-yan;Chen, Yan;Wu, Qiao
通讯作者：
Wu, Qiao