Biomaterials with Antibacterial and Osteoinductive Properties to Repair Infected Bone Defects.
Biomaterials with Antibacterial and Osteoinductive Properties to Repair Infected Bone Defects.
复制标题
具有抗菌和骨诱导特性的生物材料可修复感染的骨缺损
DOI：
10.3390/ijms17030334
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发表时间：
2016-03-03
影响因子：
5.6
通讯作者：
Wu G
中科院分区：
文献类型：
--
作者：
Lu H;Liu Y;Guo J;Wu H;Wang J;Wu G
感染性骨缺损的修复在骨科、口腔种植学和颌面外科领域仍是一个具有挑战性的课题。在这些情况下，骨组织的自愈能力可能会受到大尺寸骨缺损和潜在/活性细菌活性的显著损害。感染的骨缺损通常通过全身/局部施用抗生素以控制感染并随后植入骨移植物（例如自体移植物和同种异体移植物）来治疗。然而，这些治疗选择是耗时的，并且通常产生不太理想的疗效。为了解决这些问题，已经开发出具有抗菌和骨诱导性能的新型生物材料。抗菌性能可以通过抗生素和其他新型抗菌生物材料，如银纳米颗粒来赋予。骨形态发生蛋白用于使生物材料功能化，具有强有力的骨诱导性质。通过操纵携带模式和释放动力学，这些生物材料被优化以最大化其抗菌和骨诱导功能，同时最小化细胞毒性。近十年来的研究结果表明，具有双重功能的新型生物材料在治疗感染性骨缺损方面具有非常广阔的应用前景。在这篇综述中，我们将总结目前的知识，新型生物材料的抗菌和骨诱导性能。
The repair of infected bone defects is still challenging in the fields of orthopedics, oral implantology and maxillofacial surgery. In these cases, the self-healing capacity of bone tissue can be significantly compromised by the large size of bone defects and the potential/active bacterial activity. Infected bone defects are conventionally treated by a systemic/local administration of antibiotics to control infection and a subsequent implantation of bone grafts, such as autografts and allografts. However, these treatment options are time-consuming and usually yield less optimal efficacy. To approach these problems, novel biomaterials with both antibacterial and osteoinductive properties have been developed. The antibacterial property can be conferred by antibiotics and other novel antibacterial biomaterials, such as silver nanoparticles. Bone morphogenetic proteins are used to functionalize the biomaterials with a potent osteoinductive property. By manipulating the carrying modes and release kinetics, these biomaterials are optimized to maximize their antibacterial and osteoinductive functions with minimized cytotoxicity. The findings, in the past decade, have shown a very promising application potential of the novel biomaterials with the dual functions in treating infected bone defects. In this review, we will summarize the current knowledge of novel biomaterials with both antibacterial and osteoinductive properties.