Depolarization of mouse myeloma cell membranes during photodynamic action.
Depolarization of mouse myeloma cell membranes during photodynamic action.
复制标题
光动力作用期间小鼠骨髓瘤细胞膜的去极化。
DOI：
10.1111/j.1751-1097.1990.tb01717.x
复制
发表时间：
1990
影响因子：
3.3
通讯作者：
Rodgers,MA
中科院分区：
文献类型：
--
作者：
Specht,KG;Rodgers,MA
用荧光电位指示剂[di-SBA-C2(3)]研究了光动力作用对小鼠骨髓瘤细胞质膜电位的影响。观察到质膜去极化是光动力作用的早期事件，表现出光敏剂浓度和光剂量依赖关系。去极化发生在膜完整性保持的同时，似乎是细胞死亡之前的早期事件。
The effect of photodynamic action on plasma membranes was examined using a fluorescent potentiometric indicator [di‐SBA‐C2(3)] to measure alterations in the plasma membrane potential of mouse myeloma cells treated with zinc phthalocyanine sulfonate and light. Plasma membrane depolarization was observed to be an early event in photodynamic action, showing both photosensitizer concentration and light dose dependence. Depolarization occurred while membrane integrity was retained and appears to be an early event preceding cell death.