Persistence of memory CD8 T cells in MHC class I-deficient mice
Persistence of memory CD8 T cells in MHC class I-deficient mice
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DOI：
10.1126/science.286.5443.1377
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发表时间：
1999-11-12
期刊：
影响因子：
56.9
通讯作者：
Ahmed, R
中科院分区：
文献类型：
--
作者：
Murali-Krishna, K;Lau, LL;Ahmed, R
了解T细胞记忆是如何维持的对于疫苗的合理设计至关重要。记忆T细胞在主要组织相容性复合体（MHC）I类缺陷小鼠中无限期存在，并保留了在再次遇到抗原时快速产生细胞因子反应的能力。此外，记忆性CD 8 T细胞与幼稚细胞不同，在没有MHC-T细胞受体相互作用的情况下分裂。这种“稳态”增殖可能在维持外周记忆T细胞数量方面很重要。因此，在幼稚CD 8 T细胞分化成记忆细胞后，它们进化为MHC I类独立的“生活方式”，并且不需要用特异性或交叉反应性抗原进一步刺激以维持它们。
An understanding of how T cell memory is maintained is crucial for the rational design of vaccines. Memory T tells were shown to persist indefinitely in major histocompatibility complex (MHC) class I-deficient mice and retained the ability to make rapid cytokine responses upon reencounter with antigen. In addition, memory CD8 T cells, unlike naive cells, divided without MHC-T cell receptor interactions. This "homeostatic" proliferation is Likely to be important in maintaining memory T cell numbers in the periphery. Thus, after naive CD8 T cells differentiate into memory cells, they evolve an MHC class I-independent "life-style" and do not require further stimulation with specific or cross-reactive antigen for their maintenance.