Genetic diversity and C2-like subgenogroup strains of enterovirus 71, Taiwan, 2008.
Genetic diversity and C2-like subgenogroup strains of enterovirus 71, Taiwan, 2008.
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DOI：
10.1186/1743-422x-7-277
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发表时间：
2010-10-20
期刊：
影响因子：
4.8
通讯作者：
Wu HS
中科院分区：
文献类型：
--
作者：
Huang YP;Lin TL;Hsu LC;Chen YJ;Tseng YH;Hsu CC;Fan WB;Yang JY;Chang FY;Wu HS
已知人类肠道病毒71型（EV-71）在全球范围内引起了多次手足口病爆发和其他临床表现。2008年，台湾共分离出989株EV-71。本研究分析了这些EV-71毒株的遗传和抗原特性，并描述了台湾地区EV-71亚型的遗传多样性，其中包括3个先前报道的C5、B5和C4亚型，以及一个C2-like亚型。基于使用它们的全基因组核苷酸序列和中和试验的系统发育分析，C2样亚基因组形成与其他亚基因组遗传上不同的簇，并且抗血清显示针对该亚基因组的中和滴度最多降低128倍。此外，发现2008年的C4亚基因组分离株与近年来引起疫情的中国菌株在遗传上非常相似，因此应密切关注。本文除了是第一篇描述台湾存在C2-like亚基因群EV-71的报告外，也预测在不久的将来台湾可能会爆发C4亚基因群EV-71。
Human enterovirus 71 (EV-71) is known of having caused numerous outbreaks of hand-foot-mouth disease, and other clinical manifestations globally. In 2008, 989 EV-71 strains were isolated in Taiwan. In this study, the genetic and antigenic properties of these strains were analyzed and the genetic diversity of EV-71 subgenogroups surfacing in Taiwan was depicted, which includes 3 previously reported subgenogroups of C5, B5, and C4, and one C2-like subgenogroup. Based on the phylogenetic analyses using their complete genome nucleotide sequences and neutralization tests, the C2-like subgenogroup forms a genetically distinct cluster from other subgenogroups, and the antisera show a maximum of 128-fold decrease of neutralization titer against this subgenogroup. In addition, the subgenogroup C4 isolates of 2008 were found quite similar genetically to the Chinese strains that caused outbreaks in recent years and thus they should be carefully watched. Other than to be the first report describing the existence of C2-like subgenogroup of EV-71 in Taiwan, this article also foresees a potential of subgenogroup C4 outbreaks in Taiwan in the near future.