Cumulative health risk assessment of co-occurring mycotoxins. of deoxynivalenol and its acetyl derivatives in wheat and maize: Case study, Shanghai, China
Cumulative health risk assessment of co-occurring mycotoxins. of deoxynivalenol and its acetyl derivatives in wheat and maize: Case study, Shanghai, China
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DOI：
10.1016/j.fct.2014.10.018
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发表时间：
2014-12-01
影响因子：
4.3
通讯作者：
Wu, Aibo
中科院分区：
文献类型：
--
作者：
Han, Zheng;Nie, Dongxia;Wu, Aibo
人类自然且经常暴露于多种真菌毒素，但健康风险评估通常是针对个别真菌毒素进行的，这可能低估了总风险。在本研究中，我们首次基于浓度加法（CA）概念，评估了通过膳食摄入（DI）同时暴露于多种真菌毒素（脱氧雪腐镰刀菌醇（DON）及其3-乙酰脱氧雪腐镰刀菌醇（3-ADON）和15-乙酰脱氧雪腐镰刀菌醇（15-ADON）的乙酰基衍生物）的累积健康风险。在中国上海的7个地区进行了一项横断面研究，共有1269名参与者和330份小麦和玉米样本进行了分析。通过蒙特卡洛模拟进行概率分析，结果表明，考虑到个体真菌毒素，上海市人群没有健康风险。然而，如果综合考虑DON与3-ADON或15-ADON或两者的累积健康风险，第95百分位的DI值高达1087 ng/kg体重/天，超过了暂定最大可耐受日摄入量（PMTDI） 1000 ng/kg体重/天，因此代表了上海人群的潜在健康风险。本文提出的综合研究可作为食品安全与环境污染物共存危害累积健康风险评估的模型策略。(C) 2014 Elsevier Ltd.版权所有。
Humans are naturally and frequently exposed to a multitude of mycotoxins, but health risk assessments are usually performed on individual mycotoxins, which may underestimate the total risks. In this study, we assessed for the first time the cumulative health risks of concomitant exposure via dietary intake (DI) to multiple mycotoxins, namely deoxynivalenol (DON) and its acetyl derivatives of 3-acetyldeoxynivalenol (3-ADON) and 15-acetyldeoxynivalenol (15-ADON), based on the concentration addition (CA) concept. A cross-sectional study was conducted in seven districts in Shanghai, China with 1269 participants and 330 wheat and maize samples analyzed. After probabilistic analysis using Monte Carlo simulation, the results showed no health risks to the population in Shanghai considering individual mycotoxins. However, if the cumulative health risks were calculated based on the combined consideration of DON with either 3-ADON or 15-ADON or both, the DI values in 95th percentile were up to 1087 ng/kg body weight/day, exceeding the Provisional Maximum Tolerable Daily Intake (PMTDI) of 1000 ng/kg body weight/day and hence representing potential health risks to the population in Shanghai. The integrated study proposed here could be a model strategy for cumulative health risk assessment on the co-occurring hazards in the fields of food safety combined with environmental contaminants. (C) 2014 Elsevier Ltd. All rights reserved.