DRUG-INDUCED ALTERATIONS OF CYTOKERATIN ORGANIZATION IN CULTURED EPITHELIAL-CELLS
DRUG-INDUCED ALTERATIONS OF CYTOKERATIN ORGANIZATION IN CULTURED EPITHELIAL-CELLS
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DOI：
10.1126/science.6186022
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发表时间：
1983-01-01
期刊：
影响因子：
56.9
通讯作者：
SAWYER, RH
中科院分区：
文献类型：
--
作者：
KNAPP, LW;OGUIN, WM;SAWYER, RH
[小鼠]角蛋白中间丝的分布，以前被认为在组织中是静态的，并且不受用于改变细胞骨架的结构和组织的常规药物干扰，可以通过秋水仙碱和细胞松弛素D的治疗而显着改变。微丝和微管的损失将角蛋白细胞骨架从分支、均匀分布转变为一系列星状结构，其细丝由多个膜附着位点维持。这些发现为操纵细胞角蛋白组织、研究角蛋白在细胞骨架结构和功能中的作用提供了一种手段。
The distribution of [mouse] keratin intermediate filaments, previously considered static in organization and imperturbable by conventional drugs used to alter the structure and organization of the cytoskeleton, can be altered significantly by treatment with colchicine and cytochalasin D. The loss of microfilaments and microtubules converts the keratin cytoskeleton from a branching, even distribution to a series of starlike structures whose filaments are maintained by multiple membrane attachment sites. These findings provide a means for manipulating cytokeratin organization to investigate the role of keratins in cytoskeletal structure and function is provided.