Long-term epidemiological study of disseminated neoplasia of cockles in Galicia (NW Spain): temporal patterns at individual and population levels, influence of environmental and cockle-based factors and lethality
Long-term epidemiological study of disseminated neoplasia of cockles in Galicia (NW Spain): temporal patterns at individual and population levels, influence of environmental and cockle-based factors and lethality
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DOI：
10.1111/jfd.12436
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发表时间：
2016-09-01
影响因子：
2.5
通讯作者：
Carballal, M. J.
中科院分区：
文献类型：
--
作者：
Diaz, S.;Iglesias, D.;Carballal, M. J.
研究了影响角皮病的播散性瘤变（DN）的动态变化。在加利西亚，在个人和人口层面上都得到了解决。早期DN的特征是孤立的肿瘤细胞出现在鳃血管或鳃、外套膜、性腺或消化腺的结缔组织中。随着疾病的进展，肿瘤细胞出现松散的病灶，并广泛分布在整个器官。在晚期，大多数器官的结缔组织被肿瘤细胞浸润，这些肿瘤细胞取代了正常细胞，导致正常组织/器官结构的丧失。偶尔观察到宿主防御反应。在两个位于不同加利西亚里亚的海扇床进行了7a的实地调查，结果表明DN是一种高流行病，通常全年在成年海扇中发病率很高，但春季的年发病率最低，这可能是由于严重受影响的海扇死亡，同时性腺成熟产卵。DN发生在10 ~ 39 mm的鸟喙中，中等大小/年龄（22- 29 mm/0.7 ~ 1岁）的鸟喙中DN患病率和严重程度最高。性别似乎不影响DN的发生。DN对扇贝配子发生有抑制作用。
The dynamics of disseminated neoplasia (DN) affecting cockles Cerastoderma edule (L.) in Galicia was addressed at individual and population levels. Early stage of DN was characterized by isolated neoplastic cells occurring in branchial vessels or in the connective tissue of gills, mantle, gonad or digestive gland. As disease progressed, the neoplastic cells appeared loose in foci and became widely distributed throughout the organs. In advanced stages, the connective tissue of most organs was infiltrated by neoplastic cells, which displaced normal cells, leading to the loss of the normal tissue/organ architecture. Host defence reaction was occasionally observed. A field survey performed for 7years, in two cockle beds located in different Galician Rias, showed that DN is a hyperendemic disease usually present all year-round at high prevalence in adult cockles but with annual prevalence minima in spring likely due to the death of heavily affected cockles, concurrently with gonad ripeness-spawning. DN was detected in the cockles ranging from 10 to 39mm in size; the highest DN prevalence and severity corresponded to the cockles of intermediate size/age (22-29mm/0.7-1year old). Sex did not appear to influence DN occurrence. An inhibitory effect of DN on cockle gametogenesis was detected.