DIETARY-COMPONENTS THAT REGULATE SERUM SOMATOMEDIN-C CONCENTRATIONS IN HUMANS
DIETARY-COMPONENTS THAT REGULATE SERUM SOMATOMEDIN-C CONCENTRATIONS IN HUMANS
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DOI：
10.1172/jci110757
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发表时间：
1983-01-01
影响因子：
15.9
通讯作者：
CLEMMONS, DR
中科院分区：
文献类型：
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作者：
ISLEY, WL;UNDERWOOD, LE;CLEMMONS, DR
研究人员对5名体重正常的成年志愿者进行了评估，他们分3次禁食5天，然后再进行3种不同成分的饮食。血清生长抑素- c从预测的平均值1.85±-下降。0.39 U/ml(+-。1 SD)至0.67。禁食结束时为0.16 U/ml （P < 0.005）。正常饮食5 d后，血清生长抑素- c平均值升高至1.26 +-。0.20 U /毫升。蛋白质缺乏（对照组的32%）等热量饮食导致的增加明显较小，平均值为0.90 +-。0.24 U/ml （P < 0.05）。缺乏蛋白质和能量的饮食导致平均血清生长抑素- c浓度进一步下降至0.31 +-。0.06 U /毫升。空腹和复饲期间生长激素c的变化与平均日氮平衡显著相关（r = 0.90）。蛋白质和能量摄入都是成年人血清生长激素c浓度的明显调节因子，能量摄入可能更重要。somatomedin-C与氮平衡变化之间的相关性表明前者与蛋白质合成的变化直接相关，可能有助于评估营养治疗的反应。
Dietary components responsible for the regulation of somatomedin-C in humans were assessed in 5 adult volunteers of normal weight who were fasted for 5 days on 3 occasions, then refed 3 diets of differing composition. The serum somatomedin-C decreased from a mean prefasting value of 1.85 .+-. 0.39 U/ml (.+-. 1 SD) to 0.67 .+-. 0.16 U/ml at the end of fasting (P < 0.005). After refeeding for 5 days with a normal diet, the mean serum somatomedin-C increased to 1.26 .+-. 0.20 U/ml. A protein-deficient (32% of control), isocaloric diet resulted in a significantly smaller increase, to a mean value of 0.90 .+-. 0.24 U/ml (P < 0.05). A diet deficient in protein and energy led to a further fall in mean serum somatomedin-C concentrations to 0.31 .+-. 0.06 U/ml. The changes in somatomedin-C during fasting and refeeding correlated significantly with mean daily nitrogen balance (r = 0.90). Both protein and energy intake are apparently regulators of serum somatomedin-C concentrations in adult humans, and energy intake may be of greater importance. The correlation between changes in somatomedin-C and nitrogen balance suggests that the former are directly related to changes in protein synthesis and may be helpful in assessing the response to nutritional therapy.