Obesity, weight gain, and the risk of kidney stones
Obesity, weight gain, and the risk of kidney stones
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DOI：
10.1001/jama.293.4.455
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发表时间：
2005-01-26
影响因子：
120.7
通讯作者：
Curhan, GC
中科院分区：
文献类型：
--
作者：
Taylor, EN;Stampfer, MJ;Curhan, GC
背景较大的体型可能会导致尿钙排泄增加。草酸和尿酸，从而增加了患含钙肾结石的风险。目前尚不清楚肥胖是否会增加结石形成的风险，也不知道体重增加是否会影响风险。目的确定体重、体重增加、体重指数和腰围是否与肾结石形成有关。设计、环境和参与者：一项前瞻性研究，包括3个大型队列：Heath专业人员随访研究(N=45988名男性；基线年龄范围为40-75岁)。护士健康研究I(N=93 758名老年女性；基线年龄范围为34-59岁)和护士健康研究11(N=101 877名年轻女性，年龄范围为0 0 27-44岁)。主要结果衡量症状性肾结石的发生率。结果在总共46年的随访中，我们记录了4827例肾结石。在调整了年龄、饮食因素、液体摄入量和使用噻嗪后，体重超过220lb(100.0千克)的男性与体重小于150lb(68.2kg)的男性形成结石的相对风险(RR)为1.44(95%可信区间[CI]，1.11-1.86；趋势P=0.002)。在年长和年轻的女性中，这些体重类别的RR为1.89(95%CI，1.52-2.36；P
Context Larger body size may result in increased urinary excretion of calcium. oxalate, and uric acid, thereby increasing the risk for calcium-containing kidney stones. It is unclear if obesity increases the risk of stone formation, and it is not known if weight gain influences risk.Objective To determine if weight, weight gain, body mass index (BMI), and waist circumference are associated with kidney stone formation.Design, Setting, and Participants A prospective study of 3 large cohorts: the Heath Professionals Follow-up Study (N=45988 men; age range at baseline, 40-75 years). the Nurses' Health Study I (N =93 758 older women; age range at baseline, 34-59 years), and the Nurses' Health Study 11 (N=101 877 younger women; age range at bas-elin-e b 0 0 27-44 years).Main Outcome Measures Incidence of symptomatic kidney stones.Results We documented 4827 incident kidney stones over a combined 46 years of follow-up. After adjusting for age, dietary factors, fluid intake, and thiazide use, the relative risk (RR) for stone formation in men weighing more than 220 lb (100.0 kg) vs men less than 150 lb (68.2 kg) was 1.44 (95% confidence interval [CI], 1.11-1.86; P=.002 for trend). in older and younger women, RRs for these weight categories were 1.89 (95% Cl, 1.52-2.36; P