Assigning the positional identity of spinal motor neurons: Rostrocaudal patterning of Hox-c expression by FGFs, Gdf11, and retinoids
Assigning the positional identity of spinal motor neurons: Rostrocaudal patterning of Hox-c expression by FGFs, Gdf11, and retinoids
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DOI：
10.1016/s0896-6273(01)00544-x
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发表时间：
2001-12-26
期刊：
影响因子：
16.2
通讯作者：
Jessell, TM
中科院分区：
文献类型：
--
作者：
Liu, JP;Laufer, E;Jessell, TM
运动神经元的亚类产生于沿脊髓的吻尾轴的沿着不同位置。脊髓运动神经元的喙尾组织的一个特征是Hox基因的位置依赖性表达，但很少有人知道这方面的运动神经元亚型身份是如何分配的。我们已经使用Hox-c蛋白的表达谱来定义图案化信号的来源和身份，该图案化信号沿着脊髓的头尾轴沿着施加运动神经元位置身份。我们提供的证据表明，会聚活动的FGF，Gdf 11，和类维生素A信号起源于亨森氏结和近轴中胚层建立和完善的Hox-c的位置身份的运动神经元在脊髓的发展。
Subclasses of motor neurons are generated at different positions along the rostrocaudal axis of the spinal cord. One feature of the rostrocaudal organization of spinal motor neurons is a position-dependent expression of Hox genes, but little is known about how this aspect of motor neuron subtype identity is assigned. We have used the expression profile of Hox-c proteins to define the source and identity of patterning signals that impose motor neuron positional identity along the rostrocaudal axis of the spinal cord. We provide evidence that the convergent activities of FGFs, Gdf11, and retinoid signals originating from Hensen's node and paraxial mesoderm establish and refine the Hox-c positional identity of motor neurons in the developing spinal cord.